Related Experiment Video
Updated: Oct 14, 2025
06:59
Middle Cerebral Artery Occlusion Allowing Reperfusion via Common Carotid Artery Repair in Mice
Published on: January 23, 2019
18.0K
Role of ACE Polymorphism in Acute Ischemic Stroke
Ankit Goyal1, Alvee Saluja2, Kallur N Saraswathy3
1Department of Medicine, Lady Hardinge Medical College and Associated Hospitals, Delhi, India.
Neurology India
|November 8, 2021
Summary
The DD genotype of angiotensin-converting enzyme (ACE) polymorphism is strongly linked to an increased risk of acute ischemic stroke (AIS). This genetic factor may play a significant role in stroke development, particularly in the Indian population.
Area of Science:
- Genetics
- Cardiovascular Research
- Neurology
Background:
- Stroke is a major cause of death and disability in India.
- Angiotensin-converting enzyme (ACE) is implicated in hypertension and cerebrovascular disease.
- The genetic role of ACE polymorphism in stroke risk remains unclear.
Purpose of the Study:
- To investigate the association between ACE insertion/deletion polymorphism and acute ischemic stroke (AIS).
Main Methods:
- Recruited 130 AIS patients and 130 healthy controls.
- Analyzed DNA for ACE genotypes (II, ID, DD) using PCR and restriction digestion.
- Statistical analysis employed Chi-square tests to determine genotype associations.
Main Results:
- The DD genotype showed a significant association with stroke risk (P=0.0001).
- Both dominant and recessive models indicated DD genotype independently increases ischemic stroke risk (OR=2.848 and OR=20.732).
Conclusions:
- ACE polymorphism, specifically the DD genotype, is strongly associated with AIS risk.
- This finding supports ACE polymorphism as a potential genetic risk factor for AIS.
- Further research is warranted to confirm these genetic associations.
Related Concept Videos
01:30Acute Coronary Syndrome I: Introduction
116
Acute Coronary Syndrome (ACS) encompasses a spectrum of heart conditions caused by sudden obstruction of coronary arteries, typically resulting from the rupture of an atherosclerotic plaque and subsequent thrombus (blood clot) formation. This obstruction can lead to partial or complete blockage of blood flow, causing varying degrees of myocardial ischemia or infarction.ACS includes the following clinical entities:Unstable Angina (UA)Non-ST-Elevation Myocardial Infarction (NSTEMI)ST-Elevation...
116
01:19Acute Coronary Syndrome II: Pathophysiology and Clinical Manifestations
79
The pathophysiology of Acute Coronary Syndrome [ACD] involves several key processes:The main underlying cause of ACD is atherosclerosis, a chronic inflammatory disease characterized by the buildup of lipid-laden plaques within the coronary arteries.As the atherosclerotic plaque grows in the coronary artery, it may become unstable due to the formation of a lipid-rich core and a thin fibrous cap. Inflammatory cells within the plaque, such as macrophages, secrete enzymes that degrade the...
79
01:17Ischemic Heart Disease: Overview
2.0K
Ischemic heart disease occurs when the heart's blood supply dwindles, causing an ominous lack of oxygen and nutrients. This deficiency, stemming from reduced or obstructed blood flow, spells danger, leading to heart muscle damage and dysfunction.
Atherosclerosis, the primary malefactor, orchestrates this dangerous condition. It manifests as the accumulation of fatty deposits, akin to insidious plaques, within arterial walls. As time elapses, these plaques metamorphose, hardening and...
Atherosclerosis, the primary malefactor, orchestrates this dangerous condition. It manifests as the accumulation of fatty deposits, akin to insidious plaques, within arterial walls. As time elapses, these plaques metamorphose, hardening and...
2.0K
01:30Acute Coronary Syndrome III: Diagnostic Studies
43
Diagnosing acute coronary syndrome or ACS begins with a thorough patient history. Notable symptoms include central, crushing chest pain radiating to the left arm, neck, jaw, or back, along with shortness of breath, sweating (diaphoresis), nausea, vomiting, dizziness, and palpitations.It is crucial to note any history of cardiac illnesses and assess risk factors, including age, gender, smoking, hypertension, diabetes, hyperlipidemia, and a sedentary lifestyle.During physical examination, vital...
43
01:28Acute Coronary Syndrome IV: Interprofessional Care
49
IntroductionThe management of Acute Coronary Syndrome (ACS) aims to minimize myocardial damage, preserve myocardial function, and prevent complications.Initial ManagementInpatient management involves continuous cardiac monitoring, preferably in an ICU, focusing on blood pressure, serum sodium, potassium, and creatinine levels, and urine output. Ongoing pharmacologic management is crucial for stabilizing the patient.Supplemental Oxygen: Administer supplemental oxygen if oxygen saturation is...
49