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Updated: Oct 14, 2025

A Microwave-Assisted Direct Heteroarylation of Ketones Using Transition Metal Catalysis
Published on: February 16, 2020
β-Keto acids in asymmetric metal catalysis and organocatalysis
Wei Qin1, Mahboob Subhani1, Chunhui Jiang1
1School of Environmental and Chemical Engineering, Jiangsu University of Science and Technology, Zhenjiang, Jiangsu 212100, China. chemjiang@just.edu.cn.
Abstract:
β-Keto acids, ideal surrogates of inactive ketones, play an important role in organic synthesis. The asymmetric decarboxylative reaction using β-keto acids is the one which is being studied the most. Herein we present a comprehensive review on this research topic, which is generally classified according to different catalytic systems and chiral induction modes. Additionally, some extended utilities of these methodologies for synthesizing bioactive compounds were also summarized. This review will facilitate the synthetic community to understand the role of β-keto acids in asymmetric reactions, providing many new opportunities for further exploration in this field.
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