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A Cell Culture Model for Producing High Titer Hepatitis E Virus Stocks
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Hepatitis E virus and Bell's palsy.

Miriam Fritz-Weltin1, Lisa Niedermeier1, Estelle Frommherz1

  • 1Clinic of Neurology and Neurophysiology, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.

European Journal of Neurology
|November 8, 2021
PubMed
Summary
This summary is machine-generated.

This study found no acute Hepatitis E Virus (HEV) infections in Bell's palsy patients. Previous HEV exposure was common, suggesting further research is needed for definitive conclusions on HEV and Bell's palsy.

Keywords:
Bell's palsyHEV seroprevalencehepatitis E virus

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Area of Science:

  • Virology
  • Neurology
  • Infectious Diseases

Background:

  • Hepatitis E virus (HEV) infections are linked to neurological disorders.
  • Bell's palsy is a neurological condition with reported, but unconfirmed, associations with HEV.

Purpose of the Study:

  • To systematically investigate the association between acute HEV infection and Bell's palsy.
  • To screen a cohort of Bell's palsy patients for acute HEV infection.

Main Methods:

  • Retrospective analysis of 104 Bell's palsy patients (2008-2018).
  • Serum testing for anti-HEV IgM/IgG antibodies and HEV RNA.
  • Comparison with 263 healthy controls.

Main Results:

  • No acute HEV infections were detected in Bell's palsy patients.
  • Anti-HEV IgG seroprevalence (past infection) was 34% in Bell's palsy patients, higher than controls (0.8%).
  • Seroprevalence of past HEV infection increased with age.

Conclusions:

  • This study did not identify acute HEV as a cause of Bell's palsy.
  • Rare associations cannot be ruled out, warranting further investigation.
  • Large prospective multicenter studies are recommended for definitive conclusions.