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Microfluidic mixing system for precise PLGA-PEG nanoparticles size control.

Sara Gimondi1, Carlos F Guimarães1, Sara F Vieira1

  • 13B's Research Group, I3Bs-Research Institute on Biomaterials, Biodegradables and Biomimetics, University of Minho, Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, AvePark, Parque de Ciência e Tecnologia, Zona Industrial da Gandra, Barco, Guimarães, Portugal; ICVS/3B's-PT Government Associate Laboratory, Braga/Guimarães, Portugal.

Nanomedicine : Nanotechnology, Biology, and Medicine
|November 8, 2021
PubMed
Summary
This summary is machine-generated.

Microfluidics enables precise control over polymeric nanoparticle (NP) size for drug delivery. Smaller NPs show enhanced drug release and greater efficacy in reducing inflammation.

Keywords:
DiclofenacMicrofluidicNanoparticlesPLGA-PEGSize-control

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Area of Science:

  • Biomaterials Science
  • Nanotechnology
  • Drug Delivery Systems

Background:

  • Polymeric nanoparticles (NPs) are promising for drug delivery.
  • Controlling NP size and properties is crucial for efficacy.
  • Microfluidic technology offers precise control over nanoparticle synthesis.

Purpose of the Study:

  • To utilize microfluidics for producing size-controlled polymeric NPs.
  • To investigate the impact of NP size on drug loading, release, and biological activity.
  • To assess the cytocompatibility and anti-inflammatory efficacy of these NPs.

Main Methods:

  • Fabrication of polymeric NPs using a microfluidic device.
  • Systematic variation of synthesis parameters (polymer concentration, flow rates).
  • Characterization of NP size (30, 50, 70 nm), cytocompatibility (endothelial cells, macrophages), and in vitro drug release (diclofenac).

Main Results:

  • Microfluidics successfully produced monodisperse polymeric NPs with controlled sizes.
  • NP size influenced diclofenac (DCF) loading and release kinetics (smaller NPs: lower loading, faster release).
  • 30 nm NPs demonstrated superior efficacy in reducing prostaglandin E2 levels in an inflammatory model.

Conclusions:

  • Microfluidic synthesis provides stable, reproducible, size-controlled polymeric NPs.
  • NP size is a critical determinant for drug encapsulation, release dynamics, and therapeutic efficacy.
  • Optimized NP size enhances anti-inflammatory drug delivery performance.