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Updated: Oct 14, 2025
09:23
Plasmodium falciparum Gametocyte Culture and Mosquito Infection Through Artificial Membrane Feeding
Published on: July 3, 2020
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Plasmodium vivax gametocytes and transmission
Sirasate Bantuchai1, Hisham Imad1, Wang Nguitragool2
1Mahidol Vivax Research Unit, Faculty of Tropical Medicine, Mahidol University, 420/6 Ratchawithi Road, Ratchathewi, Bangkok 10400, Thailand.
Parasitology International
|November 8, 2021
Summary
Understanding Plasmodium vivax transmission is key to malaria elimination. This study details gametocyte characteristics and human infectivity, highlighting the role of asymptomatic carriers in perpetuating malaria parasite transmission.
Area of Science:
- * Malariology and Parasitology
- * Infectious Disease Epidemiology
Background:
- * Malaria elimination is increasingly feasible due to declining incidence, shifting focus to transmission control.
- * Plasmodium vivax transmission from humans to mosquitoes is critical for malaria persistence in endemic regions.
- * Understanding transmission dynamics is crucial for successful malaria elimination strategies.
Purpose of the Study:
- * To delineate the biological characteristics of Plasmodium vivax gametocytes, including production dynamics, longevity, and relation to parasitemia.
- * To review recent molecular advances in understanding Plasmodium vivax sexual development.
- * To assess factors influencing human infectivity and the role of asymptomatic carriers in P. vivax transmission.
Main Methods:
- * Review of fundamental gametocyte characteristics (production, longevity, parasitemia correlation).
- * Analysis of recent molecular research on Plasmodium vivax sexual development.
- * Evaluation of evidence on human infectivity factors and asymptomatic carrier transmission.
Main Results:
- * Detailed description of Plasmodium vivax gametocyte production, longevity, and relationship with overall parasitemia.
- * Recent molecular insights into the sexual development stages of the parasite.
- * Evidence supporting the contribution of asymptomatic individuals to malaria transmission.
Conclusions:
- * A comprehensive understanding of Plasmodium vivax gametocyte biology is essential for targeted interventions.
- * Molecular advancements provide new avenues for understanding and disrupting parasite transmission.
- * Asymptomatic carriers represent a significant, yet often overlooked, reservoir for sustaining P. vivax transmission, necessitating their inclusion in elimination strategies.
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