[ANTI-INFLAMMATORY EFFECTS OF BLUEBERRY PASTE LIQBERRY® IN EXPERIMENTAL TYPE 2 DIABETES]

Area of Science:

• Biochemistry
• Pharmacology
• Endocrinology

Background:

• Rising incidence of diabetes mellitus and its complications necessitates safe therapeutic strategies.
• Blueberry paste, produced via THD-technology, warrants investigation for its potential anti-inflammatory and glucose-lowering properties.

Purpose of the Study:

• To experimentally evaluate the anti-inflammatory effects of high-dose blueberry paste (Liqberry®) in a type 2 diabetes mellitus (DM 2) rat model.

Main Methods:

• Type 2 diabetes mellitus was induced in 30 female Wistar rats using protamine sulfate.
• Rats were divided into control and treatment groups, receiving blueberry paste at 8 g/kg and 20 g/kg doses.
• Blood glucose, elastase activity, and leukocyte counts were analyzed post-treatment.

Main Results:

• DM 2 induction increased blood glucose, elastase activity, and neutrophils, while decreasing lymphocytes and monocytes, indicating inflammation and immune decline.
• Blueberry paste significantly reduced blood glucose levels (15.9% at 8 g/kg, 21.2% at 20 g/kg).
• The 20 g/kg dose normalized elastase activity and neutrophil counts, and restored monocyte levels.

Conclusions:

• Blueberry paste demonstrates significant potential in reducing glucose levels and mitigating inflammation associated with DM 2.
• The high dose (20 g/kg) of blueberry paste exhibited superior efficacy in normalizing key diabetes-related inflammatory markers and immune responses.
• Blueberry paste shows promise as a preventative and therapeutic agent for type 2 diabetes mellitus.