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Lipid polymorphism.

C P Tilcock, P R Cullis

    Annals of the New York Academy of Sciences
    |January 1, 1987
    PubMed
    Summary
    This summary is machine-generated.

    Phospholipid phase behavior, crucial for cell membranes, can be studied using NMR. Alcohols influence this behavior, with short-chain alcohols stabilizing bilayers and long-chain alcohols promoting nonlamellar phases.

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    Area of Science:

    • Biochemistry and Biophysics
    • Membrane Biophysics

    Background:

    • Phospholipid phase behavior dictates membrane structure and function.
    • Lipid phase preferences are influenced by environmental factors like temperature, pH, and ions.
    • Lipid-soluble agents, including alcohols, can modulate these phase preferences.

    Purpose of the Study:

    • To investigate the influence of alcohols on phospholipid phase behavior.
    • To correlate lipid motional properties with structural organization.
    • To understand the mechanism by which alcohols affect lamellar and nonlamellar phases.

    Main Methods:

    • Utilizing Phosphorus-31 (31P) and Deuterium-2H (2H) Nuclear Magnetic Resonance (NMR) spectroscopy.
    • Monitoring phospholipid motional properties and phase preferences.

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  • Analyzing the effects of varying lipid-soluble agents (alcohols) on lipid structure.

    • Main Results:

    • Short-chain alcohols stabilize lamellar lipid structures by interacting at the membrane/water interface.
    • Longer-chain alcohols perturb acyl chain packing, promoting nonlamellar (hexagonal HII) phase formation.
    • Lipid packing and dynamic shape complementarity influence phase stability.

    Conclusions:

    • Alcohols exert differential effects on phospholipid phase behavior based on their chain length.
    • NMR techniques are effective for elucidating structure-dynamics relationships in lipid systems.
    • Understanding alcohol-lipid interactions is vital for membrane biophysics and drug design.