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Related Experiment Video

Updated: Oct 14, 2025

Characterization of Neuronal Lysosome Interactome with Proximity Labeling Proteomics

Characterization of Neuronal Lysosome Interactome with Proximity Labeling Proteomics

Published on: June 23, 2022

AIE materials for lysosome imaging.

Ankush Gupta¹, Manoj Kumar², Vandana Bhalla²

¹Department of Chemistry, DAV University, Jalandhar, Punjab, India.

Progress in Molecular Biology and Translational Science

|November 9, 2021

Summary

This summary is machine-generated.

New aggregation-induced emission (AIE) bioprobes offer enhanced photostability for precise lysosome imaging. This research reviews AIE probes for monitoring lysosome activity and evaluating therapeutic effects in biomedical applications.

Keywords:

AIE Aggregates Fluorescence Imaging Lysosome

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Area of Science:

Biomedical Engineering
Chemical Biology
Molecular Imaging

Background:

Aggregation-induced emission (AIE) active bioprobes exhibit superior photostability and signal-to-noise ratios.
There is a rapid advancement in the development of novel AIE bioimaging probes.
Lysosomes are crucial organelles involved in cellular degradation and signaling pathways.

Purpose of the Study:

To summarize lysosome-specific AIE active "turn-on" bioprobes.
To highlight their applications in lysosome imaging and bioactivity monitoring.
To provide insights for designing new AIE bioprobes for biomedical applications.

Main Methods:

Literature review of existing AIE bioprobes targeting lysosomes.
Analysis of design strategies and operational mechanisms of AIE probes.
Discussion of the utility of AIE probes in evaluating therapeutic effects.

Main Results:

AIE bioprobes enable "turn-on" fluorescence for sensitive lysosome detection.
These probes facilitate real-time monitoring of lysosome functions.
AIE probes show potential in assessing treatment efficacy and drug delivery.

Conclusions:

Lysosome-specific AIE bioprobes are powerful tools for advanced bioimaging.
Their design flexibility allows for broad applications in sensing and diagnostics.
Further development of AIE probes will enhance lysosome-related disease research and therapy.