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Related Concept Videos

Atomic Nuclei: Magnetic Resonance01:05

Atomic Nuclei: Magnetic Resonance

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The number of nuclear spins aligned in the lower energy state is slightly greater than those in the higher energy state. In the presence of an external magnetic field, as the spins precess at the Larmor frequency, the excess population results in a net magnetization oriented along the z axis. When a pulse or a short burst of radio waves at the Larmor frequency is applied along the x axis, the coupling of frequencies causes resonance and flips the nuclear spins of the excess population from the...
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Nuclear Magnetic Resonance (NMR): Overview01:07

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Nuclear magnetic resonance (NMR) is a phenomenon exhibited by certain nuclei that can absorb characteristic radio frequency radiation under certain conditions. NMR has been extensively applied in molecular spectroscopy and medical diagnostic imaging. In both these applications, the molecule or subject under study is placed in a magnetic field and irradiated with radio frequency energy.
NMR spectroscopy generates a spectrum where the characteristic absorption frequencies of the sample are...
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The Nucleus01:32

The Nucleus

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The nucleus is a membrane-bound organelle that acts as a control center in a eukaryotic cell. It contains chromosomal DNA, which controls gene expression and precisely regulates the production of proteins within the cell. In contrast, the DNA inside the mitochondria and chloroplast only carries out functions that are specific to those organelles.
Arrangement of DNA within Nucleus
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Atomic Nuclei: Nuclear Spin State Overview01:03

Atomic Nuclei: Nuclear Spin State Overview

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NMR-active nuclei have energy levels called 'spin states' that are associated with the orientations of their nuclear magnetic moments. In the absence of a magnetic field, the nuclear magnetic moments are randomly oriented, and the spin states are degenerate. When an external magnetic field is applied, the spin states have only 2 + 1 orientations available to them. A proton with = ½ has two available orientations. Similarly, for a quadrupolar nucleus with a nuclear spin value of...
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Atomic Nuclei: Nuclear Magnetic Moment00:59

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All atomic nuclei are positively charged. When they have a nonzero spin, they behave like rotating charges. As a consequence of their charge and spin, these nuclei generate a magnetic field (B). This, in turn, gives rise to a magnetic moment (μ), which is randomly oriented in the absence of an external magnetic field. When an external magnetic field (B0) is applied, the magnetic moment vectors can align with the field or against it in 2 + 1 orientations. A hydrogen nucleus, which is just a...
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Atomic Nuclei: Nuclear Spin01:08

Atomic Nuclei: Nuclear Spin

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All atomic particles possess an intrinsic angular momentum, or 'spin'. Electrons, protons, and neutrons each have a spin value of ½, although protons and neutrons in nuclei may have higher half-integer spins owing to energetic factors.
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Combining 3D Magnetic Force Actuator and Multi-Functional Fluorescence Imaging to Study Nucleus Mechanobiology
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Combining 3D Magnetic Force Actuator and Multi-Functional Fluorescence Imaging to Study Nucleus Mechanobiology

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AIE materials for nucleus imaging.

Ankit Singh1, Dhara Chaudhary1, Aishwarya P Waghchoure1

  • 1Department of Chemistry, School of Science, Indrashil University, Mehsana, India.

Progress in Molecular Biology and Translational Science
|November 9, 2021
PubMed
Summary
This summary is machine-generated.

Aggregation-induced emission (AIE) luminogens overcome issues with conventional probes, enabling advanced imaging of cell nuclei and nucleic acids for early cancer diagnosis.

Keywords:
Aggregation induced emission (AIE)Cancer cellDNDImagingNucleus

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Area of Science:

  • Materials Science
  • Biomedical Imaging
  • Organic Chemistry

Background:

  • Aggregation-induced emission (AIE) is a photophysical phenomenon attracting significant research interest.
  • Conventional fluorophores suffer from aggregation-caused quenching (ACQ), limiting their use in biological imaging.
  • Biocompatible AIE molecules are crucial for overcoming ACQ and enabling effective cellular imaging.

Purpose of the Study:

  • To review the development of AIE luminogens for imaging cellular components.
  • To highlight AIE luminogens for imaging the cell nucleus, nucleolus, and nucleic acids.
  • To showcase the potential of AIE in early cancer diagnosis.

Main Methods:

  • Development of novel AIE-active small molecules, macromolecules, and polymers.
  • Utilizing AIE luminogens for imaging specific organelles like the cell nucleus.
  • Investigating the application of AIE in diagnosing diseases, particularly cancer.

Main Results:

  • Over a decade of AIE luminogen development has yielded promising imaging agents.
  • AIE luminogens effectively image cell nucleus, nucleolus, and nucleic acids.
  • These AIE applications show potential for early cancer detection.

Conclusions:

  • AIE luminogens are essential for overcoming ACQ limitations in bioimaging.
  • AIE technology offers advanced tools for subcellular imaging and diagnostics.
  • AIE-based imaging holds significant promise for the early diagnosis of cancer.