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Cancer biology and molecular genetics of A3 adenosine receptor

Chiara Mazziotta1,2, John Charles Rotondo1,2, Carmen Lanzillotti1,2

  • 1Laboratories of Cell Biology and Molecular Genetics, Section of Experimental Medicine, Department of Medical Sciences, School of Medicine, University of Ferrara, 64/b, Fossato di Mortara Street, 44121, Ferrara, Italy.

Oncogene
|November 9, 2021
PubMed

Insights

The A3 adenosine receptor (A3AR) has a dual role in cancer, influencing tumor growth or triggering cell death. Understanding A3AR activation and ligands is key for developing new cancer therapies.

Area of Science:

  • Pharmacology
  • Oncology
  • Molecular Biology

Background:

  • The A3 adenosine receptor (A3AR) is a cell membrane protein implicated in various cancer types.
  • A3AR expression and function are tissue-specific and adenosine dose-dependent, exhibiting a dual role in cancer pathophysiology.

Purpose of the Study:

  • To review the key aspects of A3AR activation and its ligands.
  • To summarize A3AR's diverse activities in cancer.
  • To report on advancements in A3AR modulators for potential cancer therapeutics.

Main Methods:

  • Literature review of A3AR function in cancer.
  • Analysis of A3AR's dual role in tumor growth and apoptosis.
  • Summary of current A3AR modulators and their therapeutic potential.

Main Results:

  • A3AR activation can promote tumor growth, proliferation, and survival in certain contexts.
  • Conversely, A3AR activation can also induce cytostatic and apoptotic effects in other cancer types.
  • The review highlights the complex, context-dependent role of A3AR in cancer.

Conclusions:

  • A3AR represents a promising therapeutic target in oncology.
  • Further research into A3AR modulators could lead to novel cancer treatments.
  • Understanding the nuanced role of A3AR is crucial for effective therapeutic strategies.

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