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Updated: Oct 14, 2025
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Spectral Confocal Imaging of Fluorescently tagged Nicotinic Receptors in Knock-in Mice with Chronic Nicotine Administration
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Association of Nicotine Use Disorder with Neurexin 3 Gene Polymorphisms
Turk Psikiyatri Dergisi = Turkish Journal of Psychiatry
|November 9, 2021
Summary
Genetic variations in the Neurexin 3 gene (NRXN3) are linked to nicotine use disorder (NUD) risk in the Turkish population. Specific alleles at rs11624704 and rs1004212 increase the likelihood of developing nicotine addiction.
Area of Science:
- Genetics
- Neuroscience
- Psychiatry
Background:
- Nicotine use disorder (NUD) poses a significant public health challenge.
- Genetic factors are known to influence susceptibility to addiction.
- The role of Neurexin 3 gene (NRXN3) in NUD is not well understood, particularly in diverse populations.
Purpose of the Study:
- To investigate the association between specific Neurexin 3 gene (NRXN3) polymorphisms (rs 221473, rs 221497, rs1004212, and rs11624704) and nicotine use disorder (NUD).
- To examine these genetic associations within the Turkish population.
Main Methods:
- A case-control study design was employed with 200 NUD patients and 200 controls.
- Participants were aged 18-65 years.
- DNA was extracted from blood samples, and genotype detection was performed using duplex fluorescence melting curve analysis.
Main Results:
- Individuals with the AC allele at rs11624704 showed an increased risk for NUD.
- Individuals with the AG allele at rs1004212 also demonstrated a higher risk of developing nicotine addiction.
Conclusions:
- This is the first study to explore the relationship between NRXN3 gene polymorphisms and nicotine addiction in the Turkish population.
- Findings suggest a potential link between the Neurexin gene and the risk of developing nicotine use disorder in this demographic.
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