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Updated: Oct 14, 2025

Doppler Optical Coherence Tomography of Retinal Circulation
10:46

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Published on: September 18, 2012

18.9K

Dynamic volume-rendered optical coherence tomography pupillometry.

Peter M Maloca1,2,3,4, Emanuel R de Carvalho4, Pascal W Hasler2,3

  • 1Institute of Molecular and Clinical Ophthalmology Basel (IOB), Basel, Switzerland.

Acta Ophthalmologica
|November 9, 2021
PubMed
Summary
This summary is machine-generated.

This study shows that 3D pupillometry using OCT can quantify pupil function and light response. Pupillary Ejection Fraction (PEF) shows potential for monitoring eye conditions affecting pupil movement.

Keywords:
contractilitynon-arteritic anterior ischaemic optic neuropathyoptical coherence tomographypseudoexfoliation glaucomapupillary ejection fraction

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Area of Science:

  • Ophthalmology
  • Medical Imaging
  • Optometry

Background:

  • Pseudoexfoliation glaucoma (PEXG) and non-arteritic anterior ischaemic optic neuropathy (NAION) are associated with reduced iris motility.
  • Assessing intrapupillary space (IPS) changes offers insights into pupillary function in these conditions.

Purpose of the Study:

  • To evaluate intrapupillary space (IPS) changes in healthy individuals compared to patients with PEXG or NAION.
  • To assess the feasibility of using 3D swept-source optical coherence tomography (SS-OCT) for measuring iris motility in a clinical setting.

Main Methods:

  • Scotopic and photopic IPS measurements were acquired using 3D SS-OCT data.
  • Key parameters analyzed included volumetric differences, light response ratios, and pupillary ejection fraction (PEF).

Main Results:

  • Healthy subjects exhibited significantly greater IPS contractility (8.03 mm³, 100%) compared to PEXG (2.72 mm³, 33.88%) and NAION (3.03 mm³, 38.50%) patients.
  • The relative light response ratio was highest in healthy subjects (10.26, 100%) versus PEXG (4.69, 45.70%) and NAION (3.67, 35.78%).
  • Pupillary ejection fraction (PEF) was 88.11% in normals, 76.92% in PEXG, and 70.91% in NAION patients.

Conclusions:

  • 3D pupillometry via OCT provides quantitative assessment of pupil function, contractility, and light response.
  • Pupillary Ejection Fraction (PEF) emerges as a promising neuro-pupillary outcome measure for monitoring ophthalmic disorders impacting pupil function.