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Related Concept Videos

Equipments Used to Measure Body Temperature01:13

Equipments Used to Measure Body Temperature

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Body temperature can be assessed using various devices and measured in Celsius or Fahrenheit.
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Glass-bulb thermometers are hollow glass tubes with a bulb tip containing liquid such as ethanol or mercury. Historically, glass bulb mercury thermometers were the standard device to measure body temperature. Today, mercury thermometers are prohibited in many countries due to the hazardous effects of mercury and the risk of exposure if the glass bulb breaks. In general,...
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Temperature-Controlled Conversion of Boc-Protected Methylene Blue: Advancing Solid-State Time-Temperature Indicators.

Jean Michel Merkes1,2,3, Srinivas Banala1,2,3

  • 1Institute of Organic Chemistry, RWTH Aachen University, 52074, Aachen, Germany.

Chemistryopen
|November 9, 2021
PubMed
Summary
This summary is machine-generated.

A new methylene-blue derivative, BocPTDA, acts as a solid-state organic time-temperature indicator (TTI). This dye irreversibly changes color above 20°C, signaling improper cold-chain management for product safety.

Keywords:
cold-chain transportfood packagingmethylene bluesolid-state indicatorstraceless conversion

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Area of Science:

  • Materials Science
  • Chemical Engineering
  • Food Science

Background:

  • Effective cold-chain management is crucial for preserving perishable goods and ensuring consumer safety.
  • Time-temperature indicators (TTIs) offer a visual method to monitor temperature excursions in supply chains.
  • Current TTI technologies require further development for widespread consumer application.

Purpose of the Study:

  • To develop and characterize a novel organic dye for use as a solid-state time-temperature indicator.
  • To evaluate the temperature-triggered colorimetric response of the new dye for cold-chain monitoring.
  • To assess the suitability of the dye for indicating deviations from proper cold-chain conditions.

Main Methods:

  • Synthesis of a methylene-blue-based derivative, N,N,N',N'-tetramethyl-N10-Boc-phenothiazine-3,7-diamine (BocPTDA).
  • Investigation of BocPTDA's solid-state properties and color change behavior using a silicagel-coated plate.
  • Testing BocPTDA's response to temperature variations, specifically focusing on the transition point and stability at low temperatures.

Main Results:

  • BocPTDA exhibits an irreversible color change from colorless to blue-green upon heating.
  • The color transition of BocPTDA occurs reliably above 20°C.
  • No visible color change was observed for BocPTDA at temperatures of 4°C and below, indicating stability within the desired cold-chain range.

Conclusions:

  • BocPTDA is a promising candidate for a solid-state organic time-temperature indicator dye.
  • Its distinct color change above 20°C effectively signals temperature excursions indicative of cold-chain breaches.
  • BocPTDA-based TTIs can enhance consumer confidence in product quality and safety by visually confirming cold-chain integrity.