Related Experiment Video

Updated: Oct 14, 2025

Modeling and Evaluation of Murine Diabetic Cardiomyopathy Model
06:22

Modeling and Evaluation of Murine Diabetic Cardiomyopathy Model

Published on: November 29, 2024

837

S1P Signaling Pathways in Pathogenesis of Type 2 Diabetes

Qiong He1, Jiaqi Bo2, Ruihua Shen2

  • 1Department of Endocrinology, First Hospital of Shanxi Medical University, Taiyuan 030001, Shanxi Province, China.

Journal of Diabetes Research
|November 9, 2021
PubMed

Insights

Sphingosine 1 phosphate (S1P) shows promise for treating type 2 diabetes mellitus (T2DM). Research indicates S1P positively impacts T2DM pathogenesis, beta cell function, and insulin resistance.

Area of Science:

  • Biochemistry
  • Endocrinology
  • Pharmacology

Background:

  • Type 2 diabetes mellitus (T2DM) pathogenesis is complex, with current treatments having limitations.
  • The
  • Ominous Octet
  • theory describes T2DM etiology.
  • Alternative therapeutic strategies are needed due to existing drug side effects.

Purpose of the Study:

  • To review the role of Sphingosine 1 phosphate (S1P) in T2DM.
  • To analyze S1P's pharmacological mechanisms concerning T2DM pathogenesis.
  • To assess S1P as a potential therapeutic agent for T2DM.

Main Methods:

  • Literature review of recent studies on S1P and T2DM.
  • Analysis of S1P's effects on key T2DM pathological pathways.
  • Examination of S1P's impact on beta cell function and insulin sensitivity.

Main Results:

  • S1P influences T2DM pathogenesis through multiple mechanisms.
  • S1P promotes beta cell proliferation and inhibits apoptosis.
  • S1P reduces insulin resistance, protects organs from lipotoxicity, enhances incretin effects, and lowers glucagon levels.

Conclusions:

  • Sphingosine 1 phosphate (S1P) demonstrates significant potential in managing T2DM.
  • S1P's multifaceted effects suggest it could be a future therapeutic target for T2DM treatment and prevention.

More Related Videos

Author Spotlight: Exploring the Role of Inflammation in the Co-occurrence of Primary Sjogren's Syndrome and Lung Adenocarcinoma10:21

Author Spotlight: Exploring the Role of Inflammation in the Co-occurrence of Primary Sjogren's Syndrome and Lung Adenocarcinoma

Published on: September 20, 2024

569
A Protocol for Constructing a Rat Wound Model of Type 1 Diabetes05:18

A Protocol for Constructing a Rat Wound Model of Type 1 Diabetes

Published on: February 17, 2023

4.6K

Related Concept Videos

Pathophysiology of Diabetes01:20

Pathophysiology of Diabetes

Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
2.0K
The JAK-STAT Signaling Pathway01:20

The JAK-STAT Signaling Pathway

Several cytokine receptors have tightly bound Janus kinase or JAK proteins attached at their cytosolic tail. Small signaling molecules such as cytokines, growth hormones, or prolactins bind to the cytokine receptors and initiate their dimerization. The dimerization brings the cytosolic JAKs together that trans-phosphorylate and activates each other. The activated JAKs now phosphorylate cytosolic tails of the cytokine receptors, which serve as binding sites for adaptor proteins such as  SH2...
9.6K
Insulin: The Receptor and Signaling Pathways01:28

Insulin: The Receptor and Signaling Pathways

Insulin action is mediated through a receptor tyrosine kinase, akin to the IGF-1 receptor. The number of receptors per cell varies significantly, from 40 on erythrocytes to 300,000 on adipocytes and hepatocytes. The insulin receptor consists of linked α/β subunit dimers, forming a heterotetramer glycoprotein with two extracellular α subunits and two β subunits spanning the membrane. The α subunits inhibit the inherent tyrosine kinase activity of the β subunits, but...
1.7K
Interactions Between Signaling Pathways01:19

Interactions Between Signaling Pathways

Signaling cascades usually lack linearity. Multiple pathways interact and regulate one another, allowing cells to integrate and respond to diverse environmental stimuli.
Convergence and divergence, and cross-talk between signaling pathways
Two distinct signaling pathways can converge on a single functional unit, which may either be a single protein or a complex of proteins. The response is either functionally distinct or synergistic between the two pathways but different from the response...
6.6K
Diabetes Mellitus: Overview and Type I Subtype01:22

Diabetes Mellitus: Overview and Type I Subtype

Diabetes mellitus is a chronic metabolic disorder characterized by high blood glucose levels due to inadequate insulin production, insulin resistance, or both. The condition affects millions worldwide and can significantly impact their health and quality of life.
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
3.5K
Diabetes Mellitus: Type 2 and Gestational01:22

Diabetes Mellitus: Type 2 and Gestational

Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
3.2K