Related Experiment Video
Updated: Aug 10, 2026

An Optimized Evans Blue Protocol to Assess Vascular Leak in the Mouse
Published on: September 12, 2018
Effect of dexamethasone on rabbit renal prostaglandin E2 excretion: dependence on urinary flow
Abstract:
The effects of dexamethasone on urinary PGE2 excretion (UPGE2V) were investigated in rabbits that had free or restricted access to water intake. Dexamethasone, administered by rate-controlled osmotic pumps, enhanced UPGE2V in relation with urinary flow (UV) and sodium excretion (UNaV), from 290.4 +/- 36.5 to 473.4 +/- 49.5 ng/day. Under conditions of water restriction, dexamethasone had no effect on UV and UNaV but reduced UPGE2V from 235.5 +/- 19.1 to 182.6 +/- 10.5 ng/day. It is concluded that: the rise in UPGE4V observed with dexamethasone was secondary to augmented UV or UNaV and urinary PG might not reflect renal synthesis during states of altered urinary flow.
More Related Videos
08:04A Rabbit Model of Aqueous-Deficient Dry Eye Disease Induced by Concanavalin A Injection into the Lacrimal Glands: Application to Drug Efficacy Studies
Published on: January 24, 2020
07:43Establishment of a Severe Dry Eye Model Using Complete Dacryoadenectomy in Rabbits
Published on: January 8, 2020
Related Concept Videos
Renal Drug Excretion: Glomerular Filtration
Drugs gain access to the kidney via the renal artery, which progressively branches off into afferent arterioles.
Renal Drug Excretion: Tubular Secretion
Renal Drug Excretion: Effect of Urine pH, Flow Rate, and Drug pKa
The pKa of a drug,...
Drug Dosing in Renal Diseases: Measurement of Glomerular Filtration Rate