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Microneedle-mediated transdermal nanodelivery systems: a review
Shuyao Ruan1, Yongtai Zhang1, Nianping Feng1
1Department of Pharmaceutical Sciences, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China. npfeng@hotmail.com.
Biomaterials Science
|November 9, 2021
Summary
Microneedles combined with nanoparticles overcome skin barrier limitations for enhanced transdermal drug delivery. This novel system shows great potential for delivering macromolecules effectively.
Area of Science:
- Pharmacology
- Biomaterials Science
- Nanotechnology
Background:
- The stratum corneum's barrier function limits transdermal drug delivery.
- Nanoparticles offer passive enhancement but have capacity constraints.
- Microneedles create microchannels to improve skin penetration.
Purpose of the Study:
- To review microneedle-mediated nanoparticle systems for transdermal drug delivery.
- To discuss the mechanisms, classifications, and applications of this combined approach.
- To provide a reference for future research in this novel drug delivery system.
Main Methods:
- Literature review on microneedle technology and nanoparticle delivery.
- Analysis of passive and active transdermal enhancement strategies.
- Discussion of microneedle-nanoparticle interaction and skin permeation.
Main Results:
- Microneedles effectively create pathways for nanoparticle permeation.
- Combining microneedles and nanoparticles overcomes limitations of each individual approach.
- This synergistic system demonstrates significant potential for macromolecule delivery.
Conclusions:
- Microneedle-mediated nanoparticles represent a promising strategy for overcoming skin barrier challenges.
- Further research into this drug delivery system is warranted.
- This approach offers broad prospects for advanced transdermal therapeutics.
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