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Updated: Oct 14, 2025
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A Protocol for Measuring Cue Reactivity in a Rat Model of Cocaine Use Disorder
Published on: June 18, 2018
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Longitudinal changes in network engagement during cognitive control in cocaine use disorder
Kristen P Morie1, Elise E DeVito1, Marc N Potenza2
1Department of Psychiatry, Yale University School of Medicine, New Haven, 06510 CT, USA.
Drug and Alcohol Dependence
|November 9, 2021
Summary
Longitudinal changes in brain networks related to cognitive control were observed in individuals with cocaine use disorder (CUD). A longer history of cocaine use may impede these neural changes and recovery.
Area of Science:
- Neuroscience
- Cognitive Psychology
- Addiction Research
Background:
- Cocaine use disorder (CUD) is marked by impaired cognitive control.
- Effective treatments for CUD are limited.
- Brain mechanisms underlying CUD require further investigation.
Purpose of the Study:
- To investigate longitudinal changes in functional neural networks associated with cognitive control in individuals with CUD.
- To explore how these neural changes relate to cocaine use behaviors and treatment outcomes.
Main Methods:
- Secondary analysis of fMRI Stroop task data from 44 individuals with CUD across three clinical trials.
- Independent component analysis (ICA) to assess functional network engagement changes.
- Mixed linear models to test longitudinal effects and associations with cocaine use patterns and abstinence.
Main Results:
- Six functional networks related to cognitive control showed altered engagement post-treatment.
- Reduced engagement over time was observed in amygdala-striatal, middle frontal, and right-frontoparietal networks.
- Less change in the amygdala-striatal network correlated with longer cocaine use history; abstinence was linked to greater right-frontoparietal network engagement.
Conclusions:
- Neural systems supporting cognitive control may evolve during CUD treatment.
- Extended cocaine use history might obstruct network activity changes, potentially hindering recovery.
- These findings offer insights into the neural underpinnings of CUD recovery.
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