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Graves' disease associated with cholestatic jaundice and persistent diarrhoea
Siddhesh Vijay Rane1, Ravi Thanage2, Sanjay Chandnani2
1Gastroenterology, Topiwala National Medical College, Mumbai, Maharashtra, India sid.6173@gmail.com.
Abstract:
Liver involvement in Graves' disease can be seen as a part of autoimmune process or rarely, due to the direct effects of thyrotoxicosis on liver. Hyperthyroidism can also have gastrointestinal manifestations like frequent bowel movements, diarrhoea, even malabsorption with steatorrhoea. We report a 36-year-old man with hyperthyroidism, presenting with cholestatic jaundice and persistent small bowel diarrhoea. He was diagnosed to have Graves' disease and after ruling out more common causes, the cause of cholestatic jaundice was supposed to be Graves' disease. Considering this possibility, the patient was started on treatment with carbimazole. As patient's thyroid function tests started improving, he showed significant clinical and biochemical improvement from liver point of view as well.
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