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Related Experiment Video

Updated: Oct 14, 2025

Intratibial Osteosarcoma Cell Injection to Generate Orthotopic Osteosarcoma and Lung Metastasis Mouse Models

Intratibial Osteosarcoma Cell Injection to Generate Orthotopic Osteosarcoma and Lung Metastasis Mouse Models

Published on: October 28, 2021

Primary pulmonary angiosarcoma.

Muhammad Kashif Rana¹, Owais Rahman², Aiden O'Brien²

¹Respiratory Medicine, University Hospital Limerick, Limerick, Ireland mkrana2003@yahoo.com.

BMJ Case Reports

|November 10, 2021

Summary

This summary is machine-generated.

Primary pulmonary angiosarcoma, a rare vascular tumor, presents diagnostic challenges due to nonspecific symptoms. This case highlights a delayed diagnosis in a 72-year-old man initially misdiagnosed with pulmonary embolism.

Keywords:

lung cancer (oncology)pulmonary embolism respiratory cancer

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Angiogenesis in the Ischemic Rat Lung

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Published on: February 8, 2013

Area of Science:

Vascular Oncology
Thoracic Surgery
Diagnostic Imaging

Background:

Primary pulmonary angiosarcoma is an exceptionally rare vascular malignancy.
It typically presents with nonspecific symptoms, leading to delayed diagnosis and poor prognosis.
Low clinical suspicion often contributes to misdiagnosis, frequently as pulmonary embolism.

Observation:

A 72-year-old male presented with a 6-month history of progressive dyspnea, cough, presyncope, and weight loss.
Initial CT pulmonary angiogram (CTPA) suggested a large saddle pulmonary embolism.
Multidisciplinary team review and further investigations revealed a primary pulmonary artery sarcoma.

Findings:

Histological confirmation of primary pulmonary artery sarcoma.
The patient underwent left radical pneumonectomy for treatment.
This case underscores the importance of considering rare diagnoses in the differential.

Implications:

Highlights the critical need for high clinical suspicion for rare vascular tumors in pulmonary circulation.
Emphasizes the role of multidisciplinary team discussions in accurate diagnosis.
Suggests potential for improved outcomes with earlier detection and surgical intervention.