Systematic Combination of Oligonucleotides and Synthetic Polymers for Advanced Therapeutic Applications
Moohyun Han1, Jiyun Beon1, Ju Young Lee2
1Department of Materials Science and Engineering, Pohang University of Science Technology (POSTECH), Pohang, Gyeongbuk, 37673 Korea.
Macromolecular Research
|November 10, 2021
Summary
Polymeric carriers enhance oligonucleotide therapeutics by improving stability and cellular delivery. This approach overcomes biological barriers, maximizing the potential of nucleic acid-based drugs for various diseases.
Area of Science:
- Biomaterials Science
- Nanotechnology
- Therapeutics Development
Background:
- Oligonucleotide therapeutics offer high safety, potency, and specificity.
- Clinical success is limited by poor *in vivo* stability and cellular uptake.
- Polymeric carriers present a viable solution to overcome these biological barriers.
Purpose of the Study:
- To review systematic combinations of therapeutic oligonucleotides and synthetic polymers.
- To highlight the use of functionalized polymers for controlled oligonucleotide release.
- To discuss the potential of polymeric carriers in targeted therapy and immunotherapy.
Main Methods:
- Review of existing literature on oligonucleotide-polymer conjugates.
- Analysis of polymer properties enabling enhanced oligonucleotide delivery.
- Exploration of stimuli-responsive polymers for spatiotemporal control.
Main Results:
- Polymeric carriers improve oligonucleotide nuclease resistance and cellular internalization.
- Functionalized polymers allow for tunable release kinetics and targeted delivery.
- Combinations support various oligonucleotide types, including antisense oligonucleotides, siRNAs, and mRNAs.
Conclusions:
- Polymeric carriers are crucial for overcoming delivery challenges in oligonucleotide therapeutics.
- Versatile polymeric systems can unlock the full potential of oligonucleotides for advanced therapies.
- This strategy holds promise for targeted therapy and immunotherapy applications.
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