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Updated: Oct 14, 2025
Teratoma Generation in the Testis Capsule
Published on: November 7, 2011
Staged operations for a hypervascular mixed germ cell tumor with growing teratoma syndrome: a case report
Tae-Young Jung1, Hee-Jo Baek2, Seul-Kee Kim3
1Department of Neurosurgery, Chonnam National University Medical School, Chonnam National University Hwasun Hospital, Chonnam, Republic of Korea. jung-ty@chonnam.ac.kr.
Introduction:
A mixed germ cell tumor with a teratoma component can become enlarged following chemotherapy, and such an event is diagnosed as growing teratoma syndrome. Removing large, hypervascular tumors including a tumor encased by developed vasculatures from the pineal region is challenging during a single operation.
Case Report:
A 15-year-old male underwent chemotherapy for mixed germ cell tumors according to the KSPNO G082 protocol. This case of a mixed germ cell tumor with growing teratoma syndrome was recognized very early during chemotherapy. The tumor was completely removed during the staged operations. First, the anteriorly located tumor on the third ventricle was removed via the transcallosal interforniceal approach, and 1 month later, the occipital transtentorial approach was used for the pineal tumor with decreased vascularity.
Conclusion:
Performing staged operations could be recommended for large hypervascular pineal tumors, which can be safely removed during the second operation once vascularity has decreased.
