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Gallic Acid: A Potential Anti-Cancer Agent

Yuan Jiang1,2,3, Jin Pei2, Yan Zheng1

  • 1Key Laboratory of Chinese Medicine Resources Conservation, State Administration of Traditional Chinese Medicine of the People's Republic of China, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100193, China.

Chinese Journal of Integrative Medicine
|November 10, 2021
PubMed

Insights

Gallic acid (GA), a natural compound, shows significant potential as a safe and effective anti-cancer agent. Research indicates GA may offer a promising new therapeutic strategy for various cancers, including lung and prostate cancer.

Area of Science:

  • Natural product chemistry
  • Pharmacology
  • Oncology

Background:

  • Cancer remains a leading global health challenge with limitations in current chemotherapeutics, including drug resistance and adverse effects.
  • There is a critical need for novel, potent, and safe anti-cancer agents for effective treatment and prevention.
  • Gallic acid (GA), a natural phenolic compound, exhibits diverse therapeutic properties, including anti-inflammatory, anti-obesity, and anti-cancer activities.

Purpose of the Study:

  • To review the anti-cancer potential of Gallic acid (GA) across various cancer types and elucidate its underlying molecular mechanisms.
  • To conduct a bibliometric analysis of research on Gallic acid (GA) in cancer and tumor studies.
  • To identify emerging research trends and potential future research directions for GA in oncology.

Main Methods:

  • Literature review of Gallic acid's (GA) anti-cancer properties and molecular targets.
  • Bibliometric analysis of scientific publications related to Gallic acid (GA) and cancer research.
  • Synthesis of findings to assess GA's therapeutic promise and identify key cancer types for further investigation.

Main Results:

  • Gallic acid (GA) demonstrates anti-cancer effects through multiple biological pathways, including inhibition of migration, metastasis, and angiogenesis, and induction of apoptosis and cell cycle arrest.
  • Bibliometric analysis highlights lung cancer, prostate cancer, stomach cancer, and colon adenocarcinoma as areas of significant and growing research interest for GA.
  • GA exhibits potential as a safe and potent therapeutic agent, addressing limitations of traditional chemotherapy.

Conclusions:

  • Gallic acid (GA) is a promising natural compound with significant potential as a novel, safe, and effective anti-cancer therapeutic.
  • Further research focusing on GA for lung, prostate, stomach, and colon cancers is warranted.
  • GA represents a viable candidate for developing new strategies in cancer prevention and treatment.
Keywords:
applicationbibliometriccancergallic acidtumor

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