Gallic Acid: A Potential Anti-Cancer Agent

Area of Science:

• Natural product chemistry
• Pharmacology
• Oncology

Background:

• Cancer remains a leading global health challenge with limitations in current chemotherapeutics, including drug resistance and adverse effects.
• There is a critical need for novel, potent, and safe anti-cancer agents for effective treatment and prevention.
• Gallic acid (GA), a natural phenolic compound, exhibits diverse therapeutic properties, including anti-inflammatory, anti-obesity, and anti-cancer activities.

Purpose of the Study:

• To review the anti-cancer potential of Gallic acid (GA) across various cancer types and elucidate its underlying molecular mechanisms.
• To conduct a bibliometric analysis of research on Gallic acid (GA) in cancer and tumor studies.
• To identify emerging research trends and potential future research directions for GA in oncology.

Main Methods:

• Literature review of Gallic acid's (GA) anti-cancer properties and molecular targets.
• Bibliometric analysis of scientific publications related to Gallic acid (GA) and cancer research.
• Synthesis of findings to assess GA's therapeutic promise and identify key cancer types for further investigation.

Main Results:

• Gallic acid (GA) demonstrates anti-cancer effects through multiple biological pathways, including inhibition of migration, metastasis, and angiogenesis, and induction of apoptosis and cell cycle arrest.
• Bibliometric analysis highlights lung cancer, prostate cancer, stomach cancer, and colon adenocarcinoma as areas of significant and growing research interest for GA.
• GA exhibits potential as a safe and potent therapeutic agent, addressing limitations of traditional chemotherapy.

Conclusions:

• Gallic acid (GA) is a promising natural compound with significant potential as a novel, safe, and effective anti-cancer therapeutic.
• Further research focusing on GA for lung, prostate, stomach, and colon cancers is warranted.
• GA represents a viable candidate for developing new strategies in cancer prevention and treatment.