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Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice
Published on: June 8, 2022
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Elevated soluble CD163 predicts renal function deterioration in lupus nephritis: a cohort study in Eastern China
Guangxia Yang1, Naifeng Guo2, Jun Yin3
1Department of Nephrology, Affiliated Hospital of Jiangnan University, Wuxi, China.
The Journal of International Medical Research
|November 10, 2021
Summary
Soluble scavenger receptor differentiation antigen 163 (sCD163) levels correlate with lupus nephritis (LN) severity. Higher sCD163 indicates worse renal injury and poorer prognosis in LN patients, highlighting its potential as a predictive biomarker.
Area of Science:
- Nephrology
- Immunology
- Biomarker Discovery
Background:
- Lupus nephritis (LN) is a severe autoimmune disease affecting the kidneys.
- Accurate assessment of LN severity and prognosis is crucial for patient management.
Purpose of the Study:
- To investigate the association between soluble scavenger receptor differentiation antigen 163 (sCD163) and renal injury severity in LN.
- To determine if sCD163 can predict renal prognosis in patients with lupus nephritis.
Main Methods:
- Serum sCD163 levels were measured in 121 Eastern Chinese LN patients using enzyme-linked immunosorbent assays.
- Clinical data, glomerular filtration rate, and disease activity scores were collected.
- Renal biopsy analysis included pathological classification, activity index (AI), and chronicity index (CI); survival analysis used Kaplan-Meier curves.
Main Results:
- Higher sCD163 levels were associated with increased pathological classification, AI, and CI scores.
- sCD163 positively correlated with serum creatinine, blood urea nitrogen, AI, and CI, and negatively with estimated glomerular filtration rate.
- Patients with high sCD163 levels exhibited a higher incidence of renal endpoint events.
Conclusions:
- Serum sCD163 level is significantly correlated with the severity of lupus nephritis.
- sCD163 serves as a crucial indicator of poor renal prognosis in patients diagnosed with LN.
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