Related Experiment Video

Updated: Aug 19, 2026

Th17 Inflammation Model of Oropharyngeal Candidiasis in Immunodeficient Mice
08:02

Th17 Inflammation Model of Oropharyngeal Candidiasis in Immunodeficient Mice

Published on: February 18, 2015

Rechallenge of patients who developed oral candidiasis or hoarseness with beclomethasone dipropionate

G A Settipane, J N Kalliel, D E Klein

    New England and Regional Allergy Proceedings
    |March 1, 1987
    PubMed

    Insights

    Inhaled beclomethasone caused hoarseness or oral thrush in 9.5% of asthma patients. Hoarseness recurred in 60% upon re-challenge, suggesting caution when restarting this medication.

    Area of Science:

    • Pulmonology
    • Pharmacology

    Background:

    • Inhaled corticosteroids are a cornerstone of asthma management.
    • Adverse effects of inhaled beclomethasone, though generally mild, can impact patient adherence and treatment efficacy.

    Purpose of the Study:

    • To investigate the incidence and recurrence of adverse reactions, specifically hoarseness and oral thrush, associated with inhaled beclomethasone in asthmatic patients.
    • To evaluate the safety of re-challenging patients with inhaled beclomethasone after experiencing adverse events.

    Main Methods:

    • A cohort of 158 asthmatic patients receiving inhaled beclomethasone was monitored for adverse events.
    • Patients who developed hoarseness or oral thrush had their treatment paused until symptoms resolved.
    • A subset of these patients underwent re-challenge with inhaled beclomethasone to assess reaction recurrence.

    Main Results:

    • 9.5% (15/158) of patients developed hoarseness, oral thrush, or both.
    • Upon re-challenge, oral thrush did not recur in any patients.
    • Hoarseness recurred in 60% (3/5) of patients who had previously experienced this side effect.

    Conclusions:

    • While inhaled beclomethasone can cause hoarseness and oral thrush, patients may be restarted on the medication if clinically indicated.
    • Due to a high recurrence rate, re-challenging patients with inhaled beclomethasone after developing hoarseness is not recommended.
    • Concomitant use of oral prednisone and topical beclomethasone may increase the risk of these adverse events.

    More Related Videos

    Curcuminoid-Mediated Antimicrobial Photodynamic Therapy on a Murine Model of Oral Candidiasis06:39

    Curcuminoid-Mediated Antimicrobial Photodynamic Therapy on a Murine Model of Oral Candidiasis

    Published on: October 27, 2023

    Examination of Oral Candida Infection in Primary Sjögren's Syndrome Patients05:26

    Examination of Oral Candida Infection in Primary Sjögren's Syndrome Patients

    Published on: March 1, 2024

    Related Concept Videos

    Allergic Drug Reactions01:27

    Allergic Drug Reactions

    Allergic reactions related to drugs are hypersensitivity responses driven by the immune system and bear no connection to the drug's therapeutic action. While drugs in isolation do not trigger an immune response, they can interact with endogenous proteins to form antigens. These antigens stimulate lymphocytes to produce antibodies. IgE-type antibodies attach themselves to mast cells. Upon subsequent exposure to the same stimulus, the antigen-antibody interaction is initiated, unleashing numerous...
    Antiasthma Drugs: Inhaled Corticosteroids and Glucocorticoids01:25

    Antiasthma Drugs: Inhaled Corticosteroids and Glucocorticoids

    Inhaled corticosteroids (ICS) are anti-inflammatory drugs used primarily in treating persistent asthma and providing long-term maintenance. They target the bronchial mucosa, the lining of the airways, to control inflammation, a critical factor in asthma progression and exacerbation.
    ICS work through a multifaceted mechanism of action. They suppress the inflammatory response caused by the proliferation of TH cells. They also reduce the transcription of the IL-2 gene, which is involved in the...
    COPD: Management Using Bronchodilators and Corticosteroids01:26

    COPD: Management Using Bronchodilators and Corticosteroids

    Chronic obstructive pulmonary isease (COPD) involves a group of progressive lung disorders characterized by persistent airflow limitation and chronic respiratory symptoms. Asthma-COPD Overlap Syndrome (ACOS), encompassing features of both asthma and Chronic obstructive pulmonary disease (COPD), is a group of progressive lung disorders that includes chronic bronchitis, emphysema, and refractory (non-reversible) asthma. ACOS leads to complex clinical presentations that combine the inflammatory...
    Inhaled Medications01:23

    Inhaled Medications

    Inhaled medications are crucial for managing chronic obstructive pulmonary disease (COPD) and asthma. They are essential for effective treatment and control, ensuring optimal respiratory health and well-being. Inhaled medication delivers drugs directly to the lungs, providing a rapid onset of action and reducing systemic side effects compared to oral or injectable medications. Three primary types of inhalation devices are used to administer these medications: nebulizers, metered-dose inhalers...
    Candidiasis01:20

    Candidiasis

    Candidiasis is a fungal infection caused by opportunistic species of Candida. It can affect various anatomical sites, including the skin, oral cavity, nails, and genitourinary tract. Among its forms, vaginal candidiasis is the most common type of mucosal infection. It typically results from the overgrowth of Candida albicans in the vaginal mucosa. Under normal conditions, C. albicans exists as a commensal organism within the vaginal microbiota, regulated by the dominance of lactobacilli, which...
    Asthma III: Clinical Manifestations01:13

    Asthma III: Clinical Manifestations

    Asthma presents with a characteristic pattern of episodic respiratory symptoms that reflect underlying airway inflammation, bronchoconstriction, and mucus hypersecretion. Although severity varies among individuals, certain clinical manifestations are considered hallmarks of the disorder and often guide diagnosis and assessment.Respiratory SymptomsA persistent cough is one of the most common early features of asthma. It is frequently dry and tends to worsen at night or in the early morning,...