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Updated: Oct 14, 2025

MALDI Imaging Mass Spectrometry of Neuropeptides in Parkinson's Disease
Published on: February 14, 2012
Characterizing the spatial distribution of dipeptides in rodent tissue using MALDI MS imaging with on-tissue
Kening Li1, Shuai Guo2, Weiwei Tang1
1State Key Laboratory of Natural Medicines and School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing, 210009, China. weiweitang@cpu.edu.cn.
Abstract:
A highly efficient on-tissue derivatization method for the matrix-assisted laser desorption/ionization mass spectrometry imaging (MALDI MSI) of dipeptides in tissues has been developed via a combination of a home-built laser-assisted chemical transfer (LACT) technique and hexafluoroisopropanol (HFIP).
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