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Rhea, the reaction knowledgebase in 2022.

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This summary is machine-generated.

Rhea, a biochemical reaction knowledgebase, has been enhanced with improved coverage and adopted by UniProtKB for enzyme annotation. These updates aim to improve its utility for studying enzymes and metabolic systems.

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Area of Science:

  • Biochemistry and Bioinformatics
  • Molecular Biology
  • Systems Biology

Background:

  • Rhea is an expert-curated knowledgebase of biochemical reactions.
  • It is based on the Chemical Entities of Biological Interest (ChEBI) ontology.
  • The last report on Rhea was published in 2019.

Purpose of the Study:

  • To report key developments in the Rhea knowledgebase since 2019.
  • To highlight improvements in reaction coverage and resource integration.
  • To demonstrate the enhanced utility of Rhea for biological research.

Main Methods:

  • Expert curation of biochemical reactions.
  • Integration with chemical ontologies (ChEBI).
  • Adoption as a reference vocabulary by UniProtKB.

Main Results:

  • Significant improvements in Rhea's reaction coverage.
  • Rhea is now the reference vocabulary for enzyme annotation in UniProtKB.
  • A new Rhea website has been developed.
  • Rhea has been designated an ELIXIR Core Data Resource.

Conclusions:

  • Recent developments enhance Rhea's utility as a reference resource.
  • Rhea supports the study and engineering of enzymes and metabolic systems.
  • The integration and accessibility of Rhea have been significantly improved.