Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Gene-specific expression and calcium activation of Arabidopsis thaliana phospholipase C isoforms.

The New phytologist·2021
Same author

Mechanisms for controlling balance between light input and utilisation in the salt tolerant alga Dunaliella C9AA.

Photosynthesis research·2014
Same author

The effect of ionic stress on photosynthesis in Dunaliella tertiolecta : Chlorophyll fluorescence kinetics and spectral characteristics.

Planta·2013
Same author

Ileovesicostomy: update.

Archivos espanoles de urologia·2011
Same author

Numerical analysis of solutocapillary Marangoni-induced interfacial waves.

Advances in colloid and interface science·2007
Same author

Factors influencing exfiltration processes in sewers.

Water science and technology : a journal of the International Association on Water Pollution Research·2005

Related Experiment Video

Updated: Oct 13, 2025

A Microfluidic System with Surface Patterning for Investigating Cavitation Bubble(s)–Cell Interaction and the Resultant Bioeffects at the Single-cell Level
11:14

A Microfluidic System with Surface Patterning for Investigating Cavitation Bubble(s)–Cell Interaction and the Resultant Bioeffects at the Single-cell Level

Published on: January 10, 2017

11.9K

Microbubble intensification of bioprocessing.

D J Gilmour1, W B Zimmerman2

  • 1Department of Molecular Biology and Biotechnology, University of Sheffield, Sheffield, United Kingdom.

Advances in Microbial Physiology
|November 10, 2021
PubMed
Summary

Microbubbles significantly advance bioprocessing, especially in fermentation and wastewater treatment. Their unique hydrodynamic mechanisms offer substantial rate increases over conventional methods.

Keywords:
Airlift loop bioreactorsAnaerobic digestionDisinfection and detoxificationFlotation separationsFluidic oscillationHeat and mass transferIn situ product removalMicroalgaeMicrobubble distillationMicrobubblesYeast

More Related Videos

Microfluidic Picoliter Bioreactor for Microbial Single-cell Analysis: Fabrication, System Setup, and Operation
12:04

Microfluidic Picoliter Bioreactor for Microbial Single-cell Analysis: Fabrication, System Setup, and Operation

Published on: December 6, 2013

12.5K
Manufacture of Concentrated, Lipid-based Oxygen Microbubble Emulsions by High Shear Homogenization and Serial Concentration
13:17

Manufacture of Concentrated, Lipid-based Oxygen Microbubble Emulsions by High Shear Homogenization and Serial Concentration

Published on: May 26, 2014

15.2K

Related Experiment Videos

Last Updated: Oct 13, 2025

A Microfluidic System with Surface Patterning for Investigating Cavitation Bubble(s)–Cell Interaction and the Resultant Bioeffects at the Single-cell Level
11:14

A Microfluidic System with Surface Patterning for Investigating Cavitation Bubble(s)–Cell Interaction and the Resultant Bioeffects at the Single-cell Level

Published on: January 10, 2017

11.9K
Microfluidic Picoliter Bioreactor for Microbial Single-cell Analysis: Fabrication, System Setup, and Operation
12:04

Microfluidic Picoliter Bioreactor for Microbial Single-cell Analysis: Fabrication, System Setup, and Operation

Published on: December 6, 2013

12.5K
Manufacture of Concentrated, Lipid-based Oxygen Microbubble Emulsions by High Shear Homogenization and Serial Concentration
13:17

Manufacture of Concentrated, Lipid-based Oxygen Microbubble Emulsions by High Shear Homogenization and Serial Concentration

Published on: May 26, 2014

15.2K

Area of Science:

  • Bioprocessing Engineering
  • Fluid Dynamics
  • Chemical Engineering

Background:

  • Microbubbles have been used in industrial processing since the 1970s and in medical imaging since 2000.
  • Recent rapid R&D advances have led to microbubble adoption in bioprocessing, including wastewater treatment, anaerobic digestion, and fermentation.

Purpose of the Study:

  • To review microbubble generation methods suitable for industrial bioprocessing.
  • To analyze six fundamental physicochemical hydrodynamic mechanisms of microbubble innovations in bioprocessing.
  • To highlight applications in microalgal, yeast, and wastewater treatment processes.

Main Methods:

  • Brief review of microbubble generation techniques, identifying fluidic oscillation via microporous diffusers as optimal for fermentation.
  • Analysis of six core physicochemical hydrodynamic mechanisms exploited by microbubbles in bioprocessing.
  • Case studies illustrating applications in microalgal, yeast, and wastewater treatment.

Main Results:

  • Fluidic oscillation through microporous diffusers is the primary viable generation method for large-scale fermentation.
  • Six key hydrodynamic mechanisms demonstrate significant impact on bioprocessing rates.
  • Microbubble applications show substantial improvements in microalgal, yeast, and wastewater treatment processes.

Conclusions:

  • Microbubble technology, particularly fluidic oscillation, is poised for wider exploitation in industrial bioprocessing.
  • The smallest microbubbles can enhance process rates by orders of magnitude compared to conventional methods.
  • Optimized microbubble integration promises substantial advancements in biomanufacturing and pharmaceutical sectors.