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Related Concept Videos

Scale-Up Processes01:14

Scale-Up Processes

The scale-up of microbial fermentation processes is essential in industrial biotechnology, allowing the transition from laboratory-scale experiments to commercial-scale production while aiming to maintain product yield and quality. This process requires meticulous adjustment of equipment design, process parameters, and contamination control strategies to accommodate increasing culture volumes.At the laboratory scale, cultures are typically maintained in 1 to 10-liter glass or autoclavable...
Upstream Processing01:27

Upstream Processing

Upstream processing represents a critical phase in biomanufacturing, wherein biological systems such as microorganisms, mammalian cells, or insect cells are cultivated to produce therapeutic proteins, vaccines, enzymes, or other biologically derived products. This phase encompasses all steps from the selection and genetic manipulation of the production organism to the cultivation of cells in bioreactors under tightly controlled environmental conditions.Host Selection and Genetic OptimizationThe...

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Microfluidic Picoliter Bioreactor for Microbial Single-cell Analysis: Fabrication, System Setup, and Operation
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Microbubble intensification of bioprocessing.

D J Gilmour1, W B Zimmerman2

  • 1Department of Molecular Biology and Biotechnology, University of Sheffield, Sheffield, United Kingdom.

Advances in Microbial Physiology
|November 10, 2021
PubMed
Summary

Microbubbles significantly advance bioprocessing, especially in fermentation and wastewater treatment. Their unique hydrodynamic mechanisms offer substantial rate increases over conventional methods.

Keywords:
Airlift loop bioreactorsAnaerobic digestionDisinfection and detoxificationFlotation separationsFluidic oscillationHeat and mass transferIn situ product removalMicroalgaeMicrobubble distillationMicrobubblesYeast

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Area of Science:

  • Bioprocessing Engineering
  • Fluid Dynamics
  • Chemical Engineering

Background:

  • Microbubbles have been used in industrial processing since the 1970s and in medical imaging since 2000.
  • Recent rapid R&D advances have led to microbubble adoption in bioprocessing, including wastewater treatment, anaerobic digestion, and fermentation.

Purpose of the Study:

  • To review microbubble generation methods suitable for industrial bioprocessing.
  • To analyze six fundamental physicochemical hydrodynamic mechanisms of microbubble innovations in bioprocessing.
  • To highlight applications in microalgal, yeast, and wastewater treatment processes.

Main Methods:

  • Brief review of microbubble generation techniques, identifying fluidic oscillation via microporous diffusers as optimal for fermentation.
  • Analysis of six core physicochemical hydrodynamic mechanisms exploited by microbubbles in bioprocessing.
  • Case studies illustrating applications in microalgal, yeast, and wastewater treatment.

Main Results:

  • Fluidic oscillation through microporous diffusers is the primary viable generation method for large-scale fermentation.
  • Six key hydrodynamic mechanisms demonstrate significant impact on bioprocessing rates.
  • Microbubble applications show substantial improvements in microalgal, yeast, and wastewater treatment processes.

Conclusions:

  • Microbubble technology, particularly fluidic oscillation, is poised for wider exploitation in industrial bioprocessing.
  • The smallest microbubbles can enhance process rates by orders of magnitude compared to conventional methods.
  • Optimized microbubble integration promises substantial advancements in biomanufacturing and pharmaceutical sectors.