Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Imaging Studies II: Positron Emission Tomography and Scintigraphy01:25

Imaging Studies II: Positron Emission Tomography and Scintigraphy

262
Positron Emission Tomography (PET) is a medical imaging technique that provides crucial insights into the body's physiological functions at a molecular level. It is an indispensable resource for diagnosing, staging, and monitoring various illnesses, notably cancer, neurological disorders, and cardiovascular conditions.
Fundamental Principles of PET
262
Positron Emission Tomography01:29

Positron Emission Tomography

6.1K
Positron emission tomography (PET) is a medical imaging technique involving radiopharmaceuticals — substances that emit short-lived radiation. Although the first PET scanner was introduced in 1961, it took 15 more years before radiopharmaceuticals were combined with the technique and revolutionized its potential.
One of the main requirements of a PET scan is a positron-emitting radioisotope, which is produced in a cyclotron and then attached to a substance used by the part of the body...
6.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Exploring novel indenoquinoxaline Schiff bases as corrosion inhibitors for conversion coating on mild steel: ultrasonication-assisted synthesis and electrochemical and computational studies.

RSC advances·2026
Same author

Insights into novel benzo[h]quinoline-based 2-thioxothiazolidin-4-one and thiazol-4-one hybrids as potential antimicrobial, and antibiofilm candidates: Design, synthesis, molecular modeling, and in-silico ADME studies.

Bioorganic chemistry·2026
Same author

Environmental classification of synthetic methods for zinc oxide nanoparticles: a comparative review of sustainable green and conventional approaches with their diverse applications.

Nanoscale advances·2026
Same author

Tarlatamab in Previously Treated Small Cell Lung Cancer: A Real-World Experience in a Predominantly Hispanic Population with CNS Metastases.

Cancers·2026
Same author

Deep Eutectic Solvent-Mediated Nucleation Engineering of Bi<sub>2</sub>WO<sub>6</sub> Photocatalysts for Enhanced Visible Light Degradation of Organic Pollutants.

Langmuir : the ACS journal of surfaces and colloids·2026
Same author

A case report of acute carcinoid heart failure during lutetium-177 dotatate-triapine treatment for well-differentiated neuroendocrine tumors.

Frontiers in oncology·2026

Related Experiment Video

Updated: Oct 13, 2025

A Practical Guide for the Production and PET/CT Imaging of 68Ga-DOTATATE for Neuroendocrine Tumors in Daily Clinical Practice
08:55

A Practical Guide for the Production and PET/CT Imaging of 68Ga-DOTATATE for Neuroendocrine Tumors in Daily Clinical Practice

Published on: April 17, 2019

18.1K

68Ga-DOTATATE PET/CT: The Optimum Standardized Uptake Value (SUV) Internal Reference.

Ahmed Ragab1, Jianrong Wu2, Xue Ding3

  • 1Yale New Haven Health - Bridgeport Hospital, Bridgeport, Connecticut.

Academic Radiology
|November 10, 2021
PubMed
Summary
This summary is machine-generated.

Lean body mass normalized SUV (SUL) offers more reproducible measurements than body weight normalized SUV (SUVbw) in Gallium-68 DOTATATE PET/CT scans. Liver SUL is identified as the optimal internal reference for quantitative analysis.

Keywords:
DOTATATENeuroendocrine tumorPET/CTReferenceSUV

More Related Videos

Radiosynthesis, Quality Control, and Small Animal Positron Emission Tomography Imaging of 68Ga-Labelled Nano Molecules
09:55

Radiosynthesis, Quality Control, and Small Animal Positron Emission Tomography Imaging of 68Ga-Labelled Nano Molecules

Published on: October 4, 2024

593
Investigations on the GaIII Complex of EOB-DTPA and Its 68Ga Radiolabeled Analogue
11:22

Investigations on the GaIII Complex of EOB-DTPA and Its 68Ga Radiolabeled Analogue

Published on: August 17, 2016

10.1K

Related Experiment Videos

Last Updated: Oct 13, 2025

A Practical Guide for the Production and PET/CT Imaging of 68Ga-DOTATATE for Neuroendocrine Tumors in Daily Clinical Practice
08:55

A Practical Guide for the Production and PET/CT Imaging of 68Ga-DOTATATE for Neuroendocrine Tumors in Daily Clinical Practice

Published on: April 17, 2019

18.1K
Radiosynthesis, Quality Control, and Small Animal Positron Emission Tomography Imaging of 68Ga-Labelled Nano Molecules
09:55

Radiosynthesis, Quality Control, and Small Animal Positron Emission Tomography Imaging of 68Ga-Labelled Nano Molecules

Published on: October 4, 2024

593
Investigations on the GaIII Complex of EOB-DTPA and Its 68Ga Radiolabeled Analogue
11:22

Investigations on the GaIII Complex of EOB-DTPA and Its 68Ga Radiolabeled Analogue

Published on: August 17, 2016

10.1K

Area of Science:

  • Nuclear Medicine
  • Radiochemistry
  • Oncology

Background:

  • Standardized Uptake Value (SUV) is crucial for semiquantitative analysis in PET/CT scans.
  • SUV measurements are influenced by various factors beyond tumor biology.
  • Identifying reliable internal references is essential for accurate DOTA PET/CT interpretation.

Purpose of the Study:

  • To determine the optimal internal reference organ for quantitative measurements in 68Ga-DOTATATE PET/CT scans.
  • To compare the reproducibility of body weight normalized SUV (SUVbw) and lean body mass normalized SUV (SUL).
  • To evaluate the liver and spleen as potential internal reference organs.

Main Methods:

  • Retrospective analysis of 180 68Ga-DOTATATE PET/CT scans from neuroendocrine tumor patients.
  • Measurement of SUVbw and SUL in the liver and spleen.
  • Statistical comparison of variance between SUVbw and SUL using the paired Grambsch test.
  • Correlation analysis of SUVs with patient and scan characteristics using Spearman's rank correlation.

Main Results:

  • SUL demonstrated significantly lower variance than SUVbw in both liver and spleen (p < 0.0001).
  • Liver SUV measurements exhibited lower variance compared to spleen SUV measurements.
  • Liver SUL showed the lowest overall variance (3.69% ± 1.25%), indicating superior reproducibility.

Conclusions:

  • Lean body mass normalized SUV (SUL) is a more reproducible and reliable quantitative measure than SUVbw in DOTA PET/CT.
  • Liver SUL is the recommended optimal internal reference due to its lower variability and better reproducibility.
  • Standardizing internal references like liver SUL can enhance the accuracy of quantitative PET/CT imaging.