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Updated: Oct 13, 2025

Probing the Roles of Physical Forces in Early Chick Embryonic Morphogenesis
Published on: June 5, 2018
Blastocoel morphogenesis: A biophysics perspective
Mathieu Le Verge-Serandour1, Hervé Turlier1
1Center for Interdisciplinary Research in Biology (CIRB), College de France, CNRS, INSERM, Université PSL, Paris, France.
Abstract:
The blastocoel is a fluid-filled cavity characteristic of animal embryos at the blastula stage. Its emergence is commonly described as the result of cleavage patterning, but this historical view conceals a large diversity of mechanisms and overlooks many unsolved questions from a biophysics perspective. In this review, we describe generic mechanisms for blastocoel morphogenesis, rooted in biological literature and simple physical principles. We propose novel directions of study and emphasize the importance to study blastocoel morphogenesis as an evolutionary and physical continuum.
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