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Closing the structure-to-function gap for LRRK2
Valerie Tokars1, Chuyu Chen1, Loukia Parisiadou1
1Department of Pharmacology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
Trends in Biochemical Sciences
|November 10, 2021
Abstract:
Variations in the LRRK2 gene represent one of the strongest genetic factors for Parkinson's disease (PD). It has become clear that structural knowledge of the encoded large multidomain LRRK2 protein will cast light on its biological function. The new study from Myasnikov, Zhu, et al. provides a high-resolution structure of the full-length LRRK2.

