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Related Experiment Video

Updated: Oct 13, 2025

Extraction of Plant-based Capsules for Microencapsulation Applications

Extraction of Plant-based Capsules for Microencapsulation Applications

Published on: November 9, 2016

Sustained-release capsules coated via thermoforming techniques.

Lian Shen¹, Xiaohong Yu², Hui Fu¹

¹College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou, China.

European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences

|November 10, 2021

Summary

This study introduces thermoforming coating techniques for capsules, offering a solvent-free method for drug delivery. Both vacuum forming coating (VFC) and centrifugal forming coating (CFC) achieved 24-hour sustained drug release.

Keywords:

Capsule coating Centrifugal forming coating Sustained-release Thickness distribution Vacuum forming coating

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Last Updated: Oct 13, 2025

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Area of Science:

Pharmaceutical Technology
Materials Science
Drug Delivery Systems

Background:

Capsule coatings protect active pharmaceutical ingredients but are limited by gelatin shell sensitivity to heat and solvents.
Few studies have explored capsule coating techniques due to these material constraints.

Purpose of the Study:

To investigate and compare two thermoforming coating techniques: vacuum forming coating (VFC) and centrifugal forming coating (CFC).
To elucidate the underlying processes and mechanisms of VFC and CFC through rheological and mechanical property analysis.
To characterize and compare coating integrity and drug release behavior for both techniques.

Main Methods:

Utilized vacuum forming coating (VFC) and centrifugal forming coating (CFC) for capsule coating.
Investigated rheological and mechanical properties of the coating materials.
Characterized coating integrity, film thickness distribution, and drug release profiles.
Analyzed drug release data in relation to Fick's diffusion law.

Main Results:

A lower temperature was found to be more suitable for VFC compared to CFC.
Increased film thickness led to a decreased drug release rate.
Both VFC and CFC techniques produced capsules with a 24-hour sustained-release profile.
VFC resulted in a more homogeneous coating thickness distribution than CFC.

Conclusions:

Thermoforming coating techniques (VFC and CFC) provide convenient and efficient solvent-free solutions for capsule coating.
These methods are suitable for small-scale personalized coating of oral solid preparations.
The study demonstrates the potential of VFC and CFC for developing controlled-release drug delivery systems.