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Phagocytosis of Apoptotic Cells

Phagocytosis of Apoptotic Cells

Cells undergoing apoptosis form apoptotic bodies that must be removed immediately to prevent inflammation, autoimmune diseases, and necrosis. Phagocytosis is carried out by professional phagocytes such as macrophages or immature dendritic cells. Non-professional phagocytes such as epithelial cells and fibroblasts also take part in this process; however, they are not as effective as professional phagocytes.
Normal cells contain receptors that prevent them from being recognized...

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Author Spotlight: Flow Cytometric Determination of Pyroptosis in Avian Cells

Author Spotlight: Flow Cytometric Determination of Pyroptosis in Avian Cells

Published on: May 31, 2024

Approaching Neutrophil Pyroptosis.

Gabriel Sollberger¹

¹University of Dundee, School of Life Sciences, Division of Cell Signalling and Immunology, Dow Street, DD1 5EH Dundee, UK; Max Planck Institute for Infection Biology, Charitéplatz 1, 10117 Berlin, Germany.

Journal of Molecular Biology

|November 10, 2021

Summary

Neutrophils, the most common human phagocytes, may undergo pyroptosis, a pro-inflammatory cell death pathway. This review explores the mechanisms and potential resistance strategies of pyroptosis in neutrophils.

Keywords:

NET formation cell death inflammation neutrophil pyroptosis

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Area of Science:

Cellular biology
Immunology

Background:

Cell death occurs via apoptosis or lytic pathways like pyroptosis.
Pyroptosis involves inflammatory caspases, gasdermin proteins, and releases IL-1β and IL-18.
Pyroptosis is crucial for innate immunity and pathogen clearance, but research often overlooks neutrophils.

Purpose of the Study:

To investigate pyroptosis in neutrophils, the most abundant human phagocytes.
To elucidate the mechanisms underlying pyroptosis in neutrophils.
To explore potential neutrophil resistance mechanisms to pyroptosis.

Main Methods:

Literature review focusing on pyroptosis mechanisms.
Analysis of existing research on neutrophil inflammatory responses.
Comparative study of pyroptosis in different immune cell types.

Main Results:

Pyroptosis is a well-characterized lytic cell death pathway dependent on inflammatory caspases and gasdermins.
Neutrophils, despite being abundant, are less studied in the context of pyroptosis.
Evidence and mechanisms for neutrophil pyroptosis and resistance are explored.

Conclusions:

Neutrophils may undergo pyroptosis, contributing to innate immunity.
Understanding neutrophil pyroptosis is vital for innate immunity research.
Further investigation into neutrophil pyroptosis and resistance is warranted.