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High-Throughput immunogenetics for precision medicine in cancer
Andreas Agathangelidis1, Elisavet Vlachonikola2, Frederic Davi3
1Centre for Research and Technology Hellas, Institute of Applied Biosciences, Thessaloniki, Greece; Department of Biology, School of Science, National and Kapodistrian University of Athens, Athens, Greece.
Seminars in Cancer Biology
|November 10, 2021
Summary
Next-generation sequencing (NGS) immunogenetic analysis, or Immune-seq, aids precision medicine by dissecting cancer biology. Immune-seq improves diagnosis, monitoring, and understanding of immune responses in cancer patients.
Area of Science:
- Oncology
- Immunology
- Genetics
Background:
- Cancer's complexity challenges personalized therapy.
- Precision medicine integrates host, environment, and tumor data.
- Immunogenetics offers insights into cancer development and micro-environment.
Purpose of the Study:
- To highlight the clinical utility of Immune-seq in precision oncology.
- To showcase advancements in understanding cancer pathogenesis via immune repertoire analysis.
- To identify areas for improvement in realizing Immune-seq's potential.
Main Methods:
- Utilizing high-throughput next-generation sequencing (NGS) for comprehensive immune repertoire characterization.
- Applying NGS immunogenetic analysis (Immune-seq) to lymphoid malignancies.
- Studying T cell receptor clonal dynamics in clinical contexts like transplantation and immunotherapy.
Main Results:
- Immune-seq aids in diagnosing lymphoid malignancies and differentiating them from reactive conditions.
- Accurate minimal residual disease assessment is enabled by Immune-seq for disease monitoring.
- Immune-seq is crucial for understanding immune responses in transplantation and solid cancer immunotherapy.
Conclusions:
- Immune-seq is a key tool for precision medicine in oncology.
- Further development is needed to fully leverage Immune-seq's capabilities.
- Immune-seq enhances clinical decision-making in cancer care.
