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Published on: August 1, 2018
Vascular thiol isomerases: Structures, regulatory mechanisms, and inhibitor development
Chenghui Liang1, Robert Flaumenhaft2, Cai Yuan1
1College of Biological Science and Engineering, Fuzhou University, Fuzhou, Fujian 350108, China.
Abstract:
Vascular thiol isomerases (VTIs), including PDI, ERp5, ERp57, ERp72, and thioredoxin-related transmembrane protein 1 (TMX1), have important roles in platelet aggregation and thrombosis. Research on VTIs, their substrates in thrombosis, their regulatory mechanisms, and inhibitor development is an emerging and rapidly evolving area in vascular biology. Here, we describe the structures and functions of VTIs, summarize the relationship between the vascular TIs and thrombosis, and focus on the development of VTI inhibitors for antithrombotic applications.
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