Janus particles and motors: unrivaled devices for mastering (bio)sensing

Area of Science:

• Materials Science
• Nanotechnology
• Analytical Chemistry

Background:

• Janus particles possess unique dual functionalities within a single unit.
• This enables combined analytical properties, enhancing sensitivity and targeting in biosensing applications.
• Their versatility allows modification and operation in both static and dynamic modes.

Purpose of the Study:

• To review recent advances (last 5 years) in the application of Janus microparticles and micromotors for biosensing.
• To explore the role of materials and synthesis in Janus particle performance for biosensing.
• To cover electrochemical and optical biosensing strategies utilizing Janus particles and motors.

Main Methods:

• Literature review focusing on the last five years of research.
• Analysis of material properties and synthetic routes for Janus particle fabrication.
• Examination of electrochemical and optical detection mechanisms in Janus particle-based biosensors.

Main Results:

• Janus particles offer enhanced fluid mixing, increasing biosensing sensitivity.
• Targeting and capturing abilities are improved by their unique structure.
• Recent studies demonstrate their utility in both in vitro and in vivo biosensing methodologies.

Conclusions:

• Janus particles represent a versatile platform for next-generation biosensing.
• Further research into material optimization and synthetic methods will advance their capabilities.
• Future perspectives include expanding their use in complex biological systems and advanced diagnostic tools.