Familial nephropathy in Bracchi Italiani: 8 cases (2012-2019).
Amanda L Inman1, Ashley E Allen-Durrance1, Rachel E Cianciolo2
1From the Department of Small Animal Clinical Sciences, College of Veterinary Medicine, University of Florida, Gainesville, FL 32610.
Journal of the American Veterinary Medical Association
|November 10, 2021
Summary
Proteinuric kidney disease in Bracchi Italiani can present variably. Early detection of proteinuria in this breed may indicate hereditary nephropathy, with a poor prognosis once clinical signs appear.
Area of Science:
- Veterinary Nephrology
- Canine Genetics
- Animal Pathology
Background:
- Proteinuric kidney disease is a significant concern in purebred dogs.
- Hereditary nephropathies can affect various breeds, including Bracchi Italiani.
- Understanding breed-specific kidney disease is crucial for early diagnosis and management.
Purpose of the Study:
- To characterize the clinical and pathological findings in related Bracchi Italiani with proteinuric kidney disease.
- To identify potential indicators for hereditary nephropathy in the breed.
- To evaluate the outcome of affected dogs.
Main Methods:
- Retrospective review of health records from 2012-2019.
- Inclusion of Bracchi Italiani with confirmed histologic diagnoses of kidney disease.
- Analysis of signalment, clinical signs, diagnostic tests, and outcome data.
Main Results:
- Inappetence was the most common clinical sign observed.
- All dogs presented with proteinuria; four were azotemic.
- Glomerular amyloidosis was the most frequent histologic finding (6/8 dogs).
Conclusions:
- Clinical presentation of kidney disease in Bracchi Italiani can be variable.
- Proteinuria in young to middle-aged Bracchi Italiani warrants investigation for hereditary nephropathy.
- Prognosis is generally poor following the onset of clinical signs.
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