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Potential Applications and Perspectives of Humanized Mouse Models.
Weijian Ye1, Qingfeng Chen1,2
1Institute of Molecular and Cell Biology, Agency for Science, Technology and Research, Singapore.
Annual Review of Animal Biosciences
|November 10, 2021
Summary
Humanized mouse models, which involve engrafting immunodeficient mice with human tissues, are crucial for studying human diseases and testing treatments. These advanced models improve preclinical research by better mimicking human biology.
Area of Science:
- Biomedical Research
- Translational Medicine
- Immunology
Background:
- Advancing medical technology necessitates personalized and targeted disease treatments.
- Validating new treatments requires models that accurately reflect human biological systems.
- Murine models often show biological incongruencies with humans, limiting their utility for certain research.
Purpose of the Study:
- To review advancements and applications of humanized mouse models.
- To highlight their role in modeling human immune system and liver diseases.
- To discuss their contribution to translational medicine.
Main Methods:
- Utilizing immunodeficient mice engrafted with functional human tissues.
- Developing humanized mouse models for specific human biological systems (e.g., immune system, liver).
- Applying these models for disease modeling and preclinical testing.
Main Results:
- Humanized mouse models provide physiologically relevant platforms for studying human diseases.
- They enable the investigation of human-specific drug responses and pathogen interactions.
- These models enhance the accuracy of preclinical testing and disease mechanism studies.
Conclusions:
- Humanized mouse models are integral to modern biomedical research.
- They bridge the gap between animal studies and human clinical applications.
- Continued development and application of these models are vital for advancing translational medicine.
