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Treatment of Nocardia asteroides infection with trimethoprim-sulfamethoxazole

F V Cook, W E Farrar

    Southern Medical Journal
    |May 1, 1978
    PubMed

    Insights

    Trimethoprim-sulfamethoxazole (TMP-SMX) offers a more effective treatment for Nocardia asteroides infections. This combination therapy shows promising results, improving outcomes for patients with serious Nocardia infections.

    Area of Science:

    • Infectious Diseases
    • Microbiology
    • Pharmacology

    Background:

    • Nocardia asteroides infections historically have high fatality rates, despite sulfonamide therapy.
    • A need exists for more effective chemotherapeutic regimens against Nocardia asteroides.

    Observation:

    • Three serious Nocardia asteroides infections were successfully treated with trimethoprim-sulfamethoxazole (TMP-SMX).
    • A review of 15 additional cases from the literature also demonstrated successful outcomes.

    Findings:

    • Trimethoprim and sulfamethoxazole exhibit synergistic activity against Nocardia asteroides in vitro.
    • TMP-SMX achieves adequate antibacterial concentrations in blood, lung, and central nervous system tissues.

    Implications:

    • TMP-SMX represents a promising and effective treatment option for serious Nocardia asteroides infections.
    • Further clinical investigation and use of TMP-SMX are warranted for Nocardia infections.

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