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Clinical liver transplant tolerance: Recent topics
Mitsuhisa Takatsuki1, Susumu Eguchi2
1Department of Digestive and General Surgery, Graduate School of Medicine, University of the Ryukyus, Nishihara, Japan.
Journal of Hepato-Biliary-Pancreatic Sciences
|November 10, 2021
Summary
Achieving immunologic tolerance in liver transplantation is realistic. Strategies like immunosuppression weaning and regulatory T-cell therapy show promise for long-term graft acceptance, minimizing adverse effects.
Area of Science:
- Transplantation immunology
- Organ transplantation research
Background:
- Immunosuppression is critical post-transplant but carries long-term risks like organ dysfunction and malignancy.
- Achieving immunologic tolerance is the ultimate goal in organ transplantation.
- The liver is recognized for its inherent tolerogenic properties.
Purpose of the Study:
- To review protocols for inducing immunologic tolerance in clinical liver transplantation.
- To discuss current advancements in achieving immune tolerance after liver transplants.
Main Methods:
- Review of reported clinical protocols for inducing immunologic tolerance.
- Analysis of strategies including immunosuppression weaning and cell therapy.
Main Results:
- Elective weaning of immunosuppression and cell therapy are key procedures.
- Regulatory T-cell therapy has shown success in inducing definitive immunologic tolerance, particularly in living donor liver transplantation.
Conclusions:
- Inducing immunologic tolerance in liver transplantation is a realistic and developing field.
- Current research focuses on advancing these strategies for better patient outcomes.
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