Extracorporeal Therapy in Dermatology.

Area of Science:

• Dermatology
• Immunology
• Medical Technology

Background:

• Extracorporeal therapy has been used for decades to treat refractory dermatological disorders.
• Newer techniques like immunoadsorption have expanded treatment options for severe skin diseases.

Purpose of the Study:

• To review various extracorporeal therapies used in dermatology.
• To discuss their applications, recommendations, and guidelines based on clinical trials.

Main Methods:

• Extracorporeal photopheresis: Leukocytes treated with UVA and 8-methoxypsoralen.
• Double filtration plasmapheresis and Immunoadsorption: Techniques to remove immune complexes.

Main Results:

• These therapies are safe alternatives, reducing the need for toxic conventional medications.
• Immunoadsorption is increasingly used as a first-line treatment for immunobullous diseases.

Conclusions:

• Extracorporeal therapies provide effective management for recalcitrant skin conditions.
• High costs limit the widespread adoption of these advanced treatments, particularly in developing countries.