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Related Concept Videos

Local Anesthetics: Clinical Application as Spinal Anesthesia01:11

Local Anesthetics: Clinical Application as Spinal Anesthesia

887
Spinal anesthetics are given during lower abdomen and limb surgeries to block sensory and motor neurons. They are administered in the mid to low lumbar regions, primarily acting on the cauda equina's nerve roots. The blockade level depends on the local anesthetic (LA) concentration. Usually, low LA concentrations are sufficient to block sensory fibers, while only high LA concentrations block motor fibers. Other factors like injection volume and speed, the patient's posture, and the drug...
887
Depolarizing Blockers: Pharmocokinetics01:19

Depolarizing Blockers: Pharmocokinetics

406
Depolarizing blockers are administered through intravenous injection. Succinylcholine is the most common choice of depolarizing blockers in emergency clinical practices. Although they have a rapid onset, they readily diffuse away from the motor end plate into the extracellular fluid. They are metabolized by enzymes such as liver butyrylcholinesterase and plasma pseudocholinesterases. This produces a short duration of action, typically 5-10 minutes long, unlike nondepolarizing blockers, which...
406
Local Anesthetics: Clinical Application as Epidural Anesthesia01:29

Local Anesthetics: Clinical Application as Epidural Anesthesia

524
Epidural anesthetics are administered in the fat-filled epidural space, the outermost part of the spinal canal. This technique is commonly employed for pain management and anesthesia during lower abdomen and pelvis surgeries or labor and delivery.
Since epidural anesthetics can be infused through an epidural catheter, all types of drugs, including short-acting ones, can be administered. Chloroprocaine and lidocaine are examples of short and long-duration anesthetics, respectively. Bupivacaine...
524
Local Anesthetics: Clinical Application as Intravenous Regional Anesthesia01:16

Local Anesthetics: Clinical Application as Intravenous Regional Anesthesia

640
Intravenous regional anesthesia or the Bier block technique is used to anesthetize a specific limb or extremity. It uses exsanguinated or blood-drained vessels to transport local anesthetics or LAs to the peripheral nerve trunks. Lidocaine without vasoconstrictors like epinephrine is most commonly used for this technique. Other drugs used are prilocaine, ropivacaine, and chloroprocaine. Bupivacaine is not recommended for this technique due to its high cardiac toxicity.
One of the advantages of...
640
Local Anesthetics: Differential Sensitivity of Nerve Fibers01:24

Local Anesthetics: Differential Sensitivity of Nerve Fibers

1.1K
Local anesthetics (LAs) block the sodium channels of nerve trunks, sensory nerve endings, and neuromuscular junctions. Although LAs can block all kinds of nerves, the sensitivity of nerve fibers differs according to nerve types and structures. LAs are known to block myelinated fibers faster than unmyelinated ones. Also, they block pain or sensory neurons at low concentrations without affecting the motor neurons involved in muscle contractions. This helps relieve labor pain without affecting the...
1.1K

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Related Experiment Video

Updated: Oct 13, 2025

Author Spotlight: Enhancing Success of Ultrasound-Guided Neuraxial Anesthesia in Cases with Difficult Anatomy
03:14

Author Spotlight: Enhancing Success of Ultrasound-Guided Neuraxial Anesthesia in Cases with Difficult Anatomy

Published on: January 31, 2025

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Factors predicting difficult spinal block: A single centre study.

Smita Prakash1, Parul Mullick1, S Suresh Kumar2

  • 1Department of Anaesthesia and Intensive Care, Vardhman Mahavir Medical College and Safdarjung Hospital, New Delhi, India.

Journal of Anaesthesiology, Clinical Pharmacology
|November 11, 2021
PubMed
Summary
This summary is machine-generated.

First puncture success in spinal anesthesia depends on patient anatomy. However, the number of attempts needed for a successful block is influenced by both patient and provider factors, impacting overall procedural efficiency.

Keywords:
Anesthesiaspinalspinal puncturespine

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Area of Science:

  • Anesthesiology
  • Neurosurgery
  • Spinal Anesthesia

Background:

  • Dural puncture success is crucial for spinal anesthesia.
  • Factors influencing first attempt success and total attempts are not fully understood.

Purpose of the Study:

  • To assess patient, provider, technique, and equipment factors associated with first dural puncture success.
  • To identify predictors for the number of attempts required for successful dural puncture.

Main Methods:

  • Prospective observational study of 1647 adult patients undergoing spinal anesthesia.
  • Data collected on patient characteristics, anatomical landmarks, provider experience, and procedural details.
  • Difficult dural puncture defined by first puncture success and number of attempts.

Main Results:

  • First puncture success rate was 52.9%.
  • Factors associated with first puncture success included longer C7-coccyx distance, lower subarachnoid depth, good bony landmarks, and absence of spinal crowding.
  • Male gender, poor landmarks, bony deformity, and less experienced providers predicted more attempts.

Conclusions:

  • Patient anatomical factors solely influence first dural puncture success.
  • Both patient and provider factors predict the number of attempts for successful spinal block.