Squamous cell carcinoma of the vagina

Squamous cell carcinoma of the vagina is one of the least understood malignant tumors arising from the female genital tract. Vital facts on its clinical and biologic behavior are difficult to collate in a cumulative way. Its intermediate position in the pelvis makes it a difficult site to which to apply conventional methods of treatment without associated morbidity; its rareness precludes developing expertise by no more than a few therapists and allows few the opportunity to test new ideas encased in research protocols; and its variegated presentations invite individualization as the only therapeutic approach. Squamous cell carcinoma of the vagina remains an enigma among gynecologic neoplasms.