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FlexTileSource: An OpenSeadragon Extension for Efficient Whole-Slide Image Visualization.

Peter J Schüffler1,2, Gamze Gokturk Ozcan1, Hikmat Al-Ahmadie1

  • 1Department of Pathology, Memorial Sloan Kettering Cancer Center, New York City, NY, USA.

Journal of Pathology Informatics
|November 11, 2021
PubMed
Summary
This summary is machine-generated.

This study introduces FlexTileSource, improving digital slide viewer efficiency by directly serving tiles from native whole-slide image (WSI) pyramids. This optimization accelerates visualization, aiding digital pathology adoption.

Keywords:
Digital pathologyOpenSeadragonviewer optimizationwhole-slide imaging

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Area of Science:

  • Digital pathology
  • Computational pathology
  • Medical informatics

Background:

  • Web-based digital slide viewers commonly use OpenSlide and OpenSeadragon (OSD).
  • Standard viewers convert whole-slide images (WSI) to deep zoom images (DZI), a time-consuming process.
  • Viewer inefficiency hinders widespread digital pathology adoption.

Purpose of the Study:

  • To enhance digital slide visualization efficiency.
  • To eliminate the need for WSI to DZI conversion.
  • To enable direct tile serving from native WSI pyramids.

Main Methods:

  • Implemented a novel flexible tile source (FlexTileSource) for OSD.
  • The FlexTileSource accepts arbitrary native WSI pyramid structures.
  • Performance was evaluated using 8104 WSI reviewed by 207 pathologists over 40 days.

Main Results:

  • FlexTileSource accelerates field-of-view display by 67 ms on average.
  • Acceleration increases to 117 ms when WSI block size and viewer tile size are 1024 px.
  • The open-source library is available for public use.

Conclusions:

  • This study quantifies web-based slide viewer performance at scale.
  • It considers WSI block size and viewer tile size for accurate measurement.
  • Improved viewer performance can facilitate digital pathology adoption.