Advice to authors for avoiding flaws in preparation of original research manuscripts

Preparation of manuscripts of original research for publication is the final and critical step in the conduct of clinical research. Most manuscripts are rejected because of flaws in design, methodology, interpretation, and writing. Understanding the reasons for rejection can help clinical researchers in avoiding common errors in all sections of manuscript - introduction, methods, results, and discussion. The article highlights the reasons for rejection of original research manuscripts and suggests approaches to improve the quality of the manuscript.