Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Immunogenetic studies in habitual abortion.

M N Cauchi, S H Koh, B Tait

    The Australian & New Zealand Journal of Obstetrics & Gynaecology
    |February 1, 1987
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Artificial Intelligence (AI) in a Singaporean Emergency Department: Detecting fractures and reducing recalls.

    The Medical journal of Malaysia·2025
    Same author

    Recurrent versus first cervical artery dissection - a retrospective study of clinical and vascular characteristics.

    European journal of neurology·2020
    Same author

    Evidence of decreased HPV vaccine acceptance in Polish communities within Scotland.

    Vaccine·2018
    Same author

    Cervical artery dissection in two monozygotic twin-pairs.

    European journal of neurology·2017
    Same author

    Prognostic significance of pulsatile tinnitus in cervical artery dissection.

    European journal of neurology·2016
    Same author

    Anemia in young patients with ischaemic stroke.

    European journal of neurology·2015
    Same journal

    Determining the Feasibility of a No-Ultrasound Screening Tool for Early Medical Abortion in Australia.

    The Australian & New Zealand journal of obstetrics & gynaecology·2026
    Same journal

    'All In': Equitable Health Outcomes Require Culturally Safe Care for Everybody.

    The Australian & New Zealand journal of obstetrics & gynaecology·2026
    Same journal

    Benzylpenicillin Concentrations in Intrapartum Group B Streptococcus Prevention Guidelines; A Systematic Review of the Evidence.

    The Australian & New Zealand journal of obstetrics & gynaecology·2026
    Same journal

    Retrospective Cohort Study of Foetal Growth Restricted Births After 40 Weeks at an Australian Tertiary Maternity Hospital Between 2018 and 2021.

    The Australian & New Zealand journal of obstetrics & gynaecology·2026
    Same journal

    Models of Antenatal Care for Rural Indigenous Women: A Systematic Review.

    The Australian & New Zealand journal of obstetrics & gynaecology·2026
    Same journal

    Dispensing of Antiemetics During Pregnancy in Aotearoa New Zealand, 2005-2020.

    The Australian & New Zealand journal of obstetrics & gynaecology·2026
    See all related articles

    Immunological factors may influence habitual abortion. Partner HLA antigen sharing was not increased, but immunization with lymphocytes improved pregnancy outcomes in some women with recurrent pregnancy loss.

    Area of Science:

    • Reproductive Immunology
    • Obstetrics and Gynecology
    • Human Leukocyte Antigen (HLA)

    Background:

    • Habitual abortion, defined as more than three successive pregnancy losses, may involve immunological factors.
    • Investigating the role of Human Leukocyte Antigen (HLA) sharing and antibody formation in couples experiencing recurrent pregnancy loss is crucial for understanding aetiology.

    Purpose of the Study:

    • To investigate the association between Human Leukocyte Antigen (HLA) sharing between partners and the presence of anti-HLA antibodies in women with habitual abortion.
    • To evaluate the efficacy of lymphocyte immunization in improving pregnancy outcomes for couples with habitual abortion.

    Main Methods:

    • Studied 71 couples with habitual abortion.
    • Assessed Human Leukocyte Antigen (HLA)-A, B, DR sharing between partners.

    Related Experiment Videos

  • Detected anti-Human Leukocyte Antigen (HLA) antibodies in women against their partners' lymphocytes.
  • Administered lymphocyte immunization therapy and monitored seroconversion and pregnancy outcomes.

    • Main Results:

    • No significant increase in Human Leukocyte Antigen (HLA) sharing was observed between partners.
    • Anti-Human Leukocyte Antigen (HLA) antibodies were present in 18.3% of women.
    • A 61% seroconversion rate was achieved after lymphocyte immunization in women initially lacking antibodies.
    • Seven pregnancies occurred post-immunization, with 5 in cross-match positive and 2 in cross-match negative patients.
    • Growth-retarded infants were noted in three pregnancies.

    Conclusions:

    • Human Leukocyte Antigen (HLA) sharing is not a significant factor in habitual abortion.
    • Lymphocyte immunization can induce seroconversion and potentially improve pregnancy outcomes in habitual abortion cases.
    • Further research is needed to optimize lymphocyte immunization protocols and understand the implications of fetal growth restriction.