Related Experiment Video

Updated: Oct 13, 2025

Assessment of Global DNA Double-Strand End Resection using BrdU-DNA Labeling coupled with Cell Cycle Discrimination Imaging
06:44

Assessment of Global DNA Double-Strand End Resection using BrdU-DNA Labeling coupled with Cell Cycle Discrimination Imaging

Published on: April 28, 2021

4.2K

Tumor Suppressor FBXW7 and Its Regulation of DNA Damage Response and Repair

Huiyin Lan1,2, Yi Sun3,4

  • 1Department of Thoracic Radiation Oncology, Zhejiang Cancer Hospital, Cancer Hospital of University of Chinese Academy of Sciences, Hangzhou, China.

Frontiers in Cell and Developmental Biology
|November 11, 2021
PubMed

Insights

The FBXW7 tumor suppressor is crucial for DNA damage response (DDR) and repair, maintaining genomic stability. Understanding FBXW7

Area of Science:

  • Molecular Biology
  • Genetics
  • Cancer Research

Background:

  • Proper DNA damage response (DDR) and repair are vital for cellular homeostasis and genomic integrity.
  • Abnormalities in DDR/repair are linked to human cancer development.
  • FBXW7, an SCF E3 ubiquitin ligase component, functions as a tumor suppressor by degrading oncoproteins.

Purpose of the Study:

  • To review the role of FBXW7 in DNA damage response (DDR) and repair.
  • To discuss the molecular characteristics and regulatory functions of FBXW7 in DDR.
  • To explore the translational implications and future perspectives of FBXW7 in cancer therapy.

Main Methods:

  • Literature review of FBXW7 function in DDR and repair.
  • Overview of SCF-mediated ubiquitylation and DDR pathways.
  • Analysis of FBXW7's role in cellular homeostasis and tumorigenesis.

Main Results:

  • FBXW7 plays critical roles in regulating DNA damage response (DDR) and repair processes.
  • FBXW7 targets key proteins involved in cell cycle control and DNA repair.
  • Dysregulation of FBXW7 contributes to genomic instability and cancer development.

Conclusions:

  • FBXW7 is a key regulator of DDR and repair, essential for preventing cancer.
  • Targeting FBXW7 reactivation presents a potential therapeutic strategy for certain cancers.
  • Further research is needed to fully elucidate FBXW7's functions and therapeutic applications.
Keywords:
DDRDNA repairFBXW7cancerubiquitylation

More Related Videos

Immunofluorescence Imaging of DNA Damage and Repair Foci in Human Colon Cancer Cells05:18

Immunofluorescence Imaging of DNA Damage and Repair Foci in Human Colon Cancer Cells

Published on: June 9, 2020

11.3K
Visualization of DNA Repair Proteins Interaction by Immunofluorescence07:55

Visualization of DNA Repair Proteins Interaction by Immunofluorescence

Published on: June 26, 2020

10.5K

Related Concept Videos

DNA Damage can Stall the Cell Cycle02:37

DNA Damage can Stall the Cell Cycle

In response to DNA damage, cells can pause the cell cycle to assess and repair the breaks. However, the cell must check the DNA at certain critical stages during the cell cycle. If the cell cycle pauses before DNA replication, the cells will contain twice the amount of DNA. On the other hand, if cells arrest after DNA replication but before mitosis, they will contain four times the normal amount of DNA. With a host of specialized proteins at their disposal,cells must use the right protein at...
9.5K
Abnormal Proliferation02:23

Abnormal Proliferation

Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
4.7K
Nucleotide Excision Repair01:38

Nucleotide Excision Repair

DNA Distortion and Damage
Cells are regularly exposed to mutagens—factors in the environment that can damage DNA and generate mutations. UV radiation is one of the most common mutagens and is estimated to introduce a significant number of changes in DNA. These include bends or kinks in the structure, which can block DNA replication or transcription. If these errors are not fixed, the damage can cause mutations, which in turn can result in cancer or disease depending on which sequences are...
4.0K
Base Excision Repair01:54

Base Excision Repair

One of the common DNA damages is the chemical alteration of single bases by alkylation, oxidation, or deamination. The altered bases cause mispairing and strand breakage during replication. This type of damage causes minimal change to the DNA double helix structure and can be repaired by the base excision repair (BER) pathways. BER corrects damaged DNA sequences by removing the damaged base and restoring the original base sequence using the complementary strand as a template.
The first step of...
23.5K
Negative Regulator Molecules01:23

Negative Regulator Molecules

Positive regulators allow a cell to advance through cell cycle checkpoints. Negative regulators have an equally important role as they terminate a cell’s progression through the cell cycle—or pause it—until the cell meets specific criteria.
36.5K
Overview of DNA Repair02:25

Overview of DNA Repair

In order to be passed through generations, genomic DNA must be undamaged and error-free. However, every day, DNA in a cell undergoes several thousand to a million damaging events by natural causes and external factors. Ionizing radiation such as UV rays, free radicals produced during cellular respiration, and hydrolytic damage from metabolic reactions can alter the structure of DNA. Damages caused include single-base alteration, base dimerization, chain breaks, and cross-linkage.
Chemically...
32.1K