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Updated: Oct 13, 2025

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Multifunctional Magnesium Organic Framework-Based Microneedle Patch for Accelerating Diabetic Wound Healing.

Mengting Yin1, Jiayingzi Wu2, Mingwu Deng3

  • 1Department of Thoracic Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, China.

ACS Nano
|November 11, 2021
PubMed
Summary

This study introduces a novel microneedle patch for diabetic wound healing. The patch delivers magnesium and gallic acid for enhanced healing and antibacterial effects, significantly improving wound closure in diabetic mice.

Keywords:
diabetesgallic acidmagnesium organic frameworkmicroneedlewound healing

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Area of Science:

  • Biomedical Engineering
  • Materials Science
  • Regenerative Medicine

Background:

  • Diabetic wound healing presents significant challenges due to impaired biological processes.
  • Conventional treatments often lack efficacy and effective drug delivery for deep tissue penetration.
  • There is a need for advanced therapeutic strategies to address complex wound healing in diabetes.

Purpose of the Study:

  • To develop and evaluate a magnesium organic framework-based microneedle patch (MN-MOF-GO-Ag) for transdermal combination therapy in diabetic wound healing.
  • To investigate the synergistic effects of Mg2+ and gallic acid for promoting cellular processes and antioxidant defense.
  • To assess the antibacterial properties and overall therapeutic efficacy of the microneedle patch in a diabetic wound model.

Main Methods:

  • Fabrication of a microneedle patch incorporating magnesium organic frameworks (Mg-MOFs) and gallic acid within a poly(γ-glutamic acid) (γ-PGA) hydrogel.
  • Incorporation of graphene oxide-silver nanocomposites (GO-Ag) in the patch backing layer for antibacterial properties.
  • In vivo evaluation of the MN-MOF-GO-Ag patch on full-thickness cutaneous wounds in a diabetic mouse model.

Main Results:

  • The microneedle patch enabled sustained, deep-layer transdermal delivery of Mg2+ and gallic acid.
  • Mg2+ promoted cell migration and endothelial tubulogenesis, while gallic acid scavenged reactive oxygen species.
  • The GO-Ag component provided significant antibacterial effects, and the patch demonstrated accelerated wound healing in diabetic mice.

Conclusions:

  • The developed Mg-MOF-based microneedle patch offers a promising multifunctional platform for diabetic wound healing.
  • Combination therapy involving Mg2+ and gallic acid, coupled with antibacterial properties, effectively addresses key challenges in diabetic wound repair.
  • This innovative approach demonstrates significant therapeutic potential for improving outcomes in diabetic patients with chronic wounds.