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Oral Glucose Tolerance Test Predicts Episodic Memory Decline: A 10-Year Population-Based Follow-up Study
Sini Toppala1,2, Laura L Ekblad3,4, Matti Viitanen4,5,6
1Turku PET Centre, University of Turku and Turku University Hospital, Turku, Finland.
Objective:
To examine if the 2-h value of an oral glucose tolerance test (OGTT) can predict cognitive decline.
Research Design And Methods:
This study is based on a subpopulation of the Finnish population-based Health 2000 Survey and its follow-up, the Health 2011 study. Altogether, 961 individuals aged 45-74 (mean 55.6 years; 55.8% women) underwent OGTT in 2001-2002. Categorical verbal fluency, word-list learning, and word-list delayed recall were tested at baseline and at follow-up in 2011. Statistical analyses were performed with multivariable linear models adjusted for previously reported risk factors for cognitive decline.
Results:
A higher 2-h glucose value in the OGTT at baseline predicted worse performance (slope: -0.08; P = 0.01) and greater decline (slope: -0.07; P = 0.007) in the word-list delayed recall test after 10 years.
Conclusions:
Our results indicate that higher 2-h glucose values in the OGTT predict a decline in episodic memory after 10 years.
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