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Randomized Controlled Trial of a Cognitive Intervention to Improve Memory in Heart Failure
Susan J Pressler1, Miyeon Jung1, Irmina Gradus-Pizlo2
1Indiana University School of Nursing, 600 Barnhill Drive, Indianapolis, Indiana.
Journal of Cardiac Failure
|November 11, 2021
Summary
Computerized cognitive training (CCT) did not improve memory or brain-derived neurotrophic factor (BDNF) levels in heart failure (HF) patients. Nurse interventions may have contributed to improvements over time.
Area of Science:
- Cardiology
- Neurology
- Cognitive Science
Background:
- Heart failure (HF) is associated with cognitive decline.
- Evaluating interventions to improve cognitive function in HF patients is crucial.
Purpose of the Study:
- To assess the efficacy of computerized cognitive training (CCT) in improving memory and serum BDNF levels in HF patients.
- To examine the impact of CCT on secondary outcomes including working memory, IADLs, and HRQL.
Main Methods:
- A 3-arm randomized controlled trial involving 256 HF patients.
- Interventions included 8 weeks of CCT (BrainHQ), computerized crossword puzzles, and usual care, alongside weekly nurse enhancements.
- Data collected at baseline, 10 weeks, 4 months, and 8 months.
Main Results:
- No significant group differences were observed for CCT versus control groups in primary or secondary outcomes.
- All groups showed significant improvements over time in memory, working memory, IADLs, and HRQL.
- Serum BDNF levels decreased over time across all groups.
Conclusions:
- CCT did not demonstrate efficacy in improving cognitive outcomes or BDNF levels compared to active control or usual care.
- Nurse-enhancement interventions may play a role in observed improvements.
- Further research is recommended to explore nurse-led interventions combined with cognitive strategies for HF patients.
Keywords:
cognitive dysfunctioncomputerized cognitive trainingheart failurenurse-enhancement interventionMore Related Videos
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